Abstract.
A study was developed to evaluate the influence of triclabendazole (Fasinex) and netobimin (Hapasil) the antigenaemia in sheep naturally infected with Fasciola hepatica during 16 weeks. A sandwich-ELISA (enzyme-linked immunosorbent assay) using a rabbit polyclonal IgG antibody to F. hepatica antigens was employed and the data obtained were compared to those from coprological and indirect-ELISA techniques. Triclabendazole reduced the values of circulating antigens at weeks 2–4 post-treatment and faecal output at weeks 2–8 post-treatment, but antibodies showed positive values until the end of the study. Netobimin did not reduce circulating antigens of the trematode nor egg-excretion; and IgG antibodies did not decrease throughout the study.
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Sánchez-Andrade, .R., Paz-Silva, .A., Suárez, .J. et al. Effect of fasciolicides on the antigenaemia in sheep naturally infected with Fasciola hepatica . Parasitol Res 87, 609–614 (2001). https://doi.org/10.1007/s004360100425
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DOI: https://doi.org/10.1007/s004360100425