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Importance of the mutation of amino acid 200 of the isotype 1 β-tubulin gene in the benzimidazole resistance of the small-ruminant parasite Teladorsagia circumcincta

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In this work we demonstrated that the acquisition of benzimidazole (BZ) resistance in the small- ruminant parasite Teladorsagia circumcincta is linked to the selection of individuals that are characterized by a tyrosine (Tyr) at amino acid 200 of their isotype 1 β-tubulin gene. This mutation appears to be recessive, since only homozygous mutant (Tyr/Tyr) individuals survived after BZ treatment of two resistant populations in which the three genotypes (rr, rs, ss) were initially present. In comparison with natural BZ-susceptible populations, a decrease in the restriction polymorphism (RFLP) of the isotype 1 β-tubulin gene was observed in natural resistant populations. It seems that this decrease in β-tubulin polymorphism results from the selection of homozygous mutant individuals.

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Received: 5 October 1998 / Accepted: 16 December 1998

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Elard, L., Humbert, J. Importance of the mutation of amino acid 200 of the isotype 1 β-tubulin gene in the benzimidazole resistance of the small-ruminant parasite Teladorsagia circumcincta . Parasitol Res 85, 452–456 (1999). https://doi.org/10.1007/s004360050577

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  • DOI: https://doi.org/10.1007/s004360050577

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