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Biochemical alterations in paromomycin-treated Leishmania donovani promastigotes

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Abstract

Paromomycin is used for the treatment of leishmaniasis in humans, but little is known about its mechanism of action. Investigating the effect of this antibiotic on promastigotes of Leishmania donovani, we showed that inhibition of the multiplication of these parasites could be related to its effect on RNA synthesis and to modifications of membranous polar lipids and membrane fluidity, leading to altered membrane permeability.

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Authors and Affiliations

  1. Institut de Chimie des Substances Naturelles, C.N.R.S., F-91198 Gif-sur-Yvette Cedex, France Tel.: 33 (1) 69-82-30-37; Fax: 33 (1) 69-82-72-47, , , , , , FR

    M. Maarouf, Françoise Lawrence & M. Robert-Gero

  2. Service de Cytométrie, Institut des Sciences Végétales, Avenue de la Terrasse, Gif-sur-Yvette, France, , , , , , FR

    Spencer Brown

Authors
  1. M. Maarouf
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  2. Françoise Lawrence
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  3. Spencer Brown
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  4. M. Robert-Gero
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Received: 13 June 1996 / Accepted: 11 September 1996

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Maarouf, M., Lawrence, F., Brown, S. et al. Biochemical alterations in paromomycin-treated Leishmania donovani promastigotes. Parasitol Res 83, 198–202 (1997). https://doi.org/10.1007/s004360050232

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  • DOI: https://doi.org/10.1007/s004360050232

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