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Glycoprotein A is the immunodominant antigen of pneumocystis carinii in mice following immunization

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Abstract

A rapid and simple dual enzyme-linked immunosorbent assay was developed to quantitate the relative frequency of monoclonal antibodies produced against Pneumocystis carinii glycoprotein A (gpA) or other antigens of P. carinii after immunization with whole organisms. In BALB/cj mice, P. carinii gpA was clearly the immunodominant antigen, with a quarter of all hybridomas secreting antibody directed against this molecule.

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References

  • Gigliotti F (1992) Host species-specific antigenic variation of a mannosylated surface glycoprotein of Pneumocystis carinii. J Infect Dis 165:329–336

    PubMed  CAS  Google Scholar 

  • Gigliotti F, Stokes DC, Cheatham AB, Davis DS, Hughes WT (1986) Development of murine monoclonal antibodies to Pneumocystis carinii. J Infect Dis 14:315–322

    Google Scholar 

  • Gigliotti F, Ballou LR, Hughes WT, Mosley BD (1988) Purification and initial characterization of a ferret Pneumocystis carinii surface antigen. J Infect Dis 158:848–854

    PubMed  CAS  Google Scholar 

  • Peglow SL, Smulian AG, Linke MJ, Pogue CL, Nurre S, Crisler J, Phair J, Gold JWM, Armstrong D, Walzer PD (1990) Serologic responses to Pneumocystis carinii antigens in health and disease. J Infect Dis 161:296–306

    PubMed  CAS  Google Scholar 

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Gigliotti, F., McCool, T. Glycoprotein A is the immunodominant antigen of pneumocystis carinii in mice following immunization. Parasitol Res 82, 90–91 (1996). https://doi.org/10.1007/s004360050075

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  • DOI: https://doi.org/10.1007/s004360050075

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