Abstract
This case report describes a 62-year-old male fisherman who presented with persistent vomiting, headache, and behavior changes. Despite initial antibiotic and corticosteroid treatment, his condition worsened, leading to coma and subsequent death. Macro-genome sequencing of cerebrospinal fluid (CSF) revealed the presence of Naegleria fowleri infection, which had been missed during initial laboratory tests. The patient’s exposure history included sea-swimming near Zhoushan Island.
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References
Carter RF (1968) Primary amoebic meningo-encephalitis: clinical, pathological and epidemiological features of six fatal cases. J Pathol Bacteriol 96(1):1–25. https://doi.org/10.1002/path.1700960102
Heggie TW, Küpper T (2017) Surviving Naegleria fowleri infections: a successful case report and novel therapeutic approach. Travel Med Infect Dis 16:49–51. https://doi.org/10.1016/j.tmaid.2016.12.005
Martínez DY, Bravo-Cossio F, Valdivia-Tapia MDC, Carreazo NY, Cabello-Vilchez AM (2022) Successful treatment of primary amoebic meningoencephalitis using a novel therapeutic regimen including miltefosine and voriconazole. Acta Parasitol 67(3):1421–1424. https://doi.org/10.1007/s11686-022-00591-9
Monogue ML et al (2019) Minimal cerebrospinal fluid concentration of miltefosine despite therapeutic plasma levels during the treatment of amebic encephalitis. Antimicrob Agents Chemother 64(1):10–1128. https://doi.org/10.1128/aac.01127-19
Phu NH et al (2013) Fatal consequences of freshwater pearl diving. Lancet (London, England) 381(9861):176. https://doi.org/10.1016/s0140-6736(12)61730-9
Zhang LL et al (2018) Identification and molecular typing of Naegleria fowleri from a patient with primary amebic meningoencephalitis in China. Int J Infect Dis 72:28–33. https://doi.org/10.1016/j.ijid.2018.05.001
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Feng Wang provided the picture and guided the clinical diagnosis. Xiaojuan Chen, Fuping Shen, Wenchu Dai, and Jiwei Zhao participated in the clinical diagnosis and analyzed the data and discussed the manuscript. Jinlin liu guided the clinical diagnosis, analyzed the data, and wrote the manuscript.
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This study has been approved by the ethical committee of The Affiliated Hospital of Ningbo University.
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All participants involved in this study provided informed consent before their inclusion. They were informed about the purpose of the study, the procedures involved, and any potential risks or benefits. They were assured of the confidentiality and anonymity of their data. Participation in the study was voluntary, and participants had the right to withdraw at any time without facing any consequences. The consent process followed the guidelines and ethical standards set forth by The Affiliated Hospital of Medical School, Ningbo University.
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Wang, F., Shen, F., Dai, W. et al. A primary amoebic meningoencephalitis case associated with swimming in seawater. Parasitol Res 122, 2451–2452 (2023). https://doi.org/10.1007/s00436-023-07934-z
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DOI: https://doi.org/10.1007/s00436-023-07934-z