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The anticoccidial activity of the fluoroquinolone lomefloxacin against experimental Eimeria tenella infection in broiler chickens

  • Treatment and Prophylaxis - Original Paper
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Abstract

Coccidiosis is a crucial parasitic disease of the poultry industry. As a result of the enormous global economic losses and the increased resistance to the conventional anticoccidial agents, there is a continuous need to find new anticoccidials. Here, the anticoccidial effect of the fluoroquinolone lomefloxacin versus diclazuril in experimentally infected broilers was tested for the treatment of Eimeria tenella infection. Ninety 14-day-old Cobb strain broiler chickens were allocated into five groups, each with 18 chicks. Group 1 (G1) was separated as an uninfected negative control and received no treatment; group 2 (G2), infected untreated (positive control); group 3 (G3), infected and treated with lomefloxacin at a dose rate of 100 ppm in drinking water; group 4 (G4), infected and treated with diclazuril at a dose rate of 2.5 ppm in drinking water; group 5 (G5), infected and treated with lomefloxacin at a dose rate of 100 ppm plus diclazuril at dose rate of 2.5 ppm in drinking water. Clinical signs, mortality rates, number of oocysts per gram of faeces (OPG), growth performance parameters (weight gain: WG and feed conversion ratio: FCR), lesion scoring, haematological and serum biochemical analyses, antioxidant biomarkers and histopathologic inspection of the caeca were used as evaluation criteria for the anticoccidial efficacy of both lomefloxacin and diclazuril. The findings herein showed that administration of lomefloxacin and/or diclazuril improved growth performance parameters (WG, FCR) and significantly (P ≤ 0.05) reduced OPG, and diminished the severity of bloody diarrhoea and mortalities. Additionally, haematological indices and serum biochemical parameters such as ALT, AST, ALP, creatinine, uric acid, total proteins, albumin and globulin were improved. Finally, a significant elevation in the levels of the antioxidant biomarkers was observed in the chicks of G3, G4 and G5 as compared with those of G2.

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Authors and Affiliations

  1. Pharmacology Department, Faculty of Veterinary Medicine, KafrElsheikh University, Kafr El-Sheikh, Egypt

    Kamal Ahmed El-Shazly, Amera Abd El-Latif & Magdy Ibrahim Abd El-Aziz

  2. Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, KafrElsheikh University, Kafr El-Sheikh, Egypt

    Walied Abdo

  3. Parasitology and Animal Diseases Department, Veterinary Research Division, National Research Centre, 33 El Bohouth St. (former El-Tahrir St.), Dokki, P.O. 12622, Giza, Egypt

    Ahmed El-Morsey

  4. Poultry Production and Medicine Unit, Veterinary Administration, Kafr El-Sheikh, Kafr El-Sheikh Province, Egypt

    Heba El-Mogazy

Authors
  1. Kamal Ahmed El-Shazly
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  2. Amera Abd El-Latif
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  3. Walied Abdo
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  4. Ahmed El-Morsey
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  5. Magdy Ibrahim Abd El-Aziz
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  6. Heba El-Mogazy
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Contributions

Ahmed El-Morsey designed and conceptualized the study, analyzed data and wrote the manuscript; Kamal Ahmed El-Shazly, Amera Abd El-Latif, Walied Abdo, Heba El-Mogazy and Magdy Ibrahim Abd El-Aziz assisted in design, performed the experiment and analyzed the biochemical and haematlogical assayes, histopathological investigations and Statistical analyses. Ahmed El-Morsey and Walied Abdo performed and helped assesment of histopathological changes associated with the Eimeria tenella infection. All authors read and approved the final version of the manuscript.

Corresponding author

Correspondence to Ahmed El-Morsey.

Ethics declarations

The examined animals were handled according to the regulatory laws and ethical considerations approved by the Medical Research Ethics Committee (MREC) of the National Research Centre (NRC), Egypt for the use of experimental animals (No: 1281/2018; 10-23-2018).

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The authors declare that they have no conflicts of interest.

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El-Shazly, K.A., El-Latif, A.A., Abdo, W. et al. The anticoccidial activity of the fluoroquinolone lomefloxacin against experimental Eimeria tenella infection in broiler chickens. Parasitol Res 119, 1955–1968 (2020). https://doi.org/10.1007/s00436-020-06692-6

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