Parasitology Research

, Volume 118, Issue 3, pp 733–742 | Cite as

Chemical composition, Aedes mosquito larvicidal activity, and repellent activity against Triatoma rubrofasciata of Severinia monophylla leaf essential oil

  • Prabodh Satyal
  • Ho Viet Hieu
  • Nguyen Thi Hong Chuong
  • Nguyen Huy HungEmail author
  • Le Hoang Sinh
  • Pham Van The
  • Thieu Anh Tai
  • Vu Thi Hien
  • William N. SetzerEmail author
Arthropods and Medical Entomology - Original Paper


Aedes aegypti and Ae. albopictus are key vectors in the spread of arboviruses such as dengue, chikungunya, yellow fever, and Zika. Triatoma rubrofasciata is an “assassin bug” whose populations and association with humans have dramatically increased and may represent a serious health concern. Control of insect vectors is a logical course of action to prevent the spread of these insect-borne infections. This work presents the leaf essential oil composition, mosquito larvicidal activities, and insect-repellent activity of Severinia monophylla. The essential oil of S. monophylla from Vietnam was obtained by hydrodistillation and analyzed by gas chromatography and mass spectrometry. The major components were sabinene, β-caryophyllene, bicyclogermacrene, germacrene D, (E)-nerolidol, globulol, and linalool. The leaf essential oil showed remarkable larvicidal activity against Ae. aegypti with LC50 (48 h) of 7.1 μg/mL and Ae. albopictus with LC50 (48 h) of 36 μg/mL. The essential oil also showed repellent activity on T. rubrofasciata at a concentration of 0.5%.


Dengue fever Trypanosomiasis Sabinene β-Caryophyllene Vector control Vietnam 



The authors are grateful to Duy Tan University for financial support of this research project. P.S. and W.N.S. participated in this work as part of the activities of the Aromatic Plant Research Center (APRC,; we are grateful to dōTERRA International ( for the financial support of the APRC.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Aromatic Plant Research CenterLehiUSA
  2. 2.Parasitology and Entomology Unit, Department of MedicineDuy Tan UniversityDa NangVietnam
  3. 3.Center for Advanced Chemistry, Institute of Research and DevelopmentDuy Tan UniversityDa NangVietnam
  4. 4.Center of Scientific Research and PracticeThu Dau Mot UniversityThu Dau Mot cityVietnam
  5. 5.Department of PharmacyDuy Tan UniversityDa NangVietnam
  6. 6.Faculty of HydrometerologyHo Chi Minh City University of Natural Resources and EnvironmentHo Chi Minh CityVietnam
  7. 7.Department of ChemistryUniversity of Alabama in HuntsvilleHuntsvilleUSA

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