Abstract
The molluscicidal activity of a novel molluscicide (niclosamidate) was evaluated in field trials against Oncomelania hupensis, the intermediate host of Schistosoma japonicum. The environmental safety of niclosamidate for local fishes was also studied under field conditions. The results showed that, at the dosages of 8.0 g/m2 and 4.0 g/m3, niclosamidate exhibits highly potent molluscicidal activity in the spraying and immersion trials, resulting in mortality rates of up to 81.8 and 72.7%, respectively. Its performance seems to be target-specific, with good molluscicidal ability observed for Oncomelania hupensis snails, but very low toxicity for local fishes and other aquatic organisms. The results suggest that niclosamidate can be used as an alternative molluscicide for snail control, which would be particularly applicable in semi-commercial or commercial aquaculture ponds.
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References
Garjito TA, Sudomo M, Abdullah DM, Nurwidayati A (2008) Schistosomiasis in Indonesia: past and present. Parasitol Int 57:277–280
Leenstra T, Acosta LP, Langdon GC, Manalo DL, Su L, Olveda RM, McGarvey ST, Kurtis JD, Friedman JF (2006) Schistosomiasis japonica, anemia, and iron status in children, adolescents, and young adults in Leyte, Philippines 1. Am J Clin Nutr 83:371–379
Mitchell AJ, Hobbs MS, Brandt TM (2007) The effect of chemical treatments on red-rim melania Melanoides tuberculata, an exotic aquatic snail that serves as a vector of trematodes to fish and other species in the USA. N Am J Fish Manag 27:1287–1293
Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J (2006) Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet. Infect Dis 6:411–425
Wang L, Wang Z, Liu C et al (2000) Ministry of Health of the People’s Republic of China, Schistosomiasis prevention handbook, 3rd edn. Shanghai Science and Technique Press, Shanghai, pp 201–206 (in Chinese)
Wang W, Qin Z, Zhu D, Wei Y, Li S, Duan L (2015) Synthesis, bioactivity evaluation, and toxicity assessment of novel salicylanilide ester derivatives as cercaricides against Schistosoma japonicum and molluscicides against Oncomelania hupensis. Antimicrob Agents Chemother 60:323–331
Yang GJ, Li W, Sun LP, Wu F, Yang K, Huang YX, Zhou XN (2010) Molluscicidal efficacies of different formulations of niclosamide: result of meta-analysis of Chinese literature. Parasit Vectors 3:84
Yang GJ, Sun LP, Hong QB, Zhu HR, Yang K, Gao Q, Zhou XN (2012) Optimizing molluscicide treatment strategies in different control stages of schistosomiasis in the People’s Republic of China. Parasit Vectors 5:260
Zhou YB, Song L, Jiang QW (2012) Factors impacting on progress towards elimination of transmission of schistosomiasis japonica in China. Parasites Vectors 5:275
Acknowledgements
The authors would like to thank Ms. Yi Tao for HPLC analyses, Prof. Haobing Zhang and Dali Prefecture Institute of Schistosomiasis Prevention and Control for helpful discussion.
Funding
This study was funded by the National Key R&D Program of China (2017YFC1200600).
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Wang, W., Zhang, X., Zhang, H. et al. Field evaluation of a novel molluscicide (niclosamidate) against Oncomelania hupensis, intermediate host of Schistosoma japonicum . Parasitol Res 116, 3423–3427 (2017). https://doi.org/10.1007/s00436-017-5649-x
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DOI: https://doi.org/10.1007/s00436-017-5649-x