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Wound healing and cancer progression in Opisthorchis viverrini associated cholangiocarcinoma

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Abstract

Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). It was shown previously that O. viverrini-secreted proteins accelerate wound resolution in human cholangiocytes. Recombinant Ov-GRN-1 (O. viverrini-derived gene encoding granulin-like growth factor) induced angiogenesis and accelerated mouse wound healing. Given the striking similarities of wound healing and cancer progression, here we discuss the major implications of this finding for an infection-induced cancer of major public health significance in the developing world.

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Acknowledgments

This work was financed by FEDER–Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT–Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Inovação in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274).

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Authors and Affiliations

  1. INSA—National Institute of Health Dr. Ricardo Jorge, Rua Alexandre Herculano, 321, 4000-055, Porto, Portugal

    Monica C. Botelho & Helena Alves

  2. I3S, Instituto de Investigação e Inovação da Universidade do Porto, Porto, Portugal

    Monica C. Botelho

  3. Tropical Medicine Unit, Department for Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany

    Joachim Richter

Authors
  1. Monica C. Botelho
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  2. Helena Alves
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  3. Joachim Richter
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Correspondence to Monica C. Botelho.

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Botelho, M.C., Alves, H. & Richter, J. Wound healing and cancer progression in Opisthorchis viverrini associated cholangiocarcinoma. Parasitol Res 115, 2913–2914 (2016). https://doi.org/10.1007/s00436-016-5090-6

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  • DOI: https://doi.org/10.1007/s00436-016-5090-6

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