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Efficacy of a topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel (Broadline®) against naturally acquired infections with cestodes of the genus Joyeuxiella in cats

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Abstract

Cats are host to dipylidiid cestodes of the genera Diplopylidium, Dipylidium and Joyeuxiella. Broadline®, a topical broad-spectrum combination parasiticide containing fipronil (8.3 % w/v), (S)-methoprene (10 % w/v), eprinomectin (0.4 % w/v) and the cestocide praziquantel (8.3 % w/v), has previously been shown to be efficacious against Dipylidium caninum and Diplopylidium spp. in cats. To evaluate its efficacy against Joyeuxiella species, a blinded clinical efficacy study was conducted according to GCP. All cats had evidence for naturally acquired dipylidiid cestode infection as confirmed by pre-treatment examination. Cats were allocated randomly to two groups of 13 cats each based on bodyweight: Control (untreated) and Broadline® at 0.12 mL/kg bodyweight administered once topically. Based on the comparison of helminth counts in the treated and untreated cats seven days post treatment, Broadline® demonstrated >99 % efficacy (p < 0.01) against mature J. fuhrmanni and J. pasqualei, with 11 and 13 of the untreated cats harbouring 1 to 102 or 2 to 95 cestodes, respectively. In addition, parasite counts indicated 95.9 % efficacy (p = 0.006) against the rictularoid nematode Pterygodermatites cahirensis.

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Authors and Affiliations

  1. Central Veterinary Research Laboratory, Dubai, United Arab Emirates

    Rolf K. Schuster & Jagadeesan Vijay Baskar

  2. Veterinary Services Section, Dubai Municipality, Dubai, United Arab Emirates

    Murad Basheer Mustafa

  3. Merial, Inc., Duluth, GA, 30096, USA

    Joseph Rosentel & S. Theodore Chester

  4. Merial GmbH, Kathrinenhof Research Center, 83101, Rohrdorf, Germany

    Martin Knaus

Authors
  1. Rolf K. Schuster
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  2. Murad Basheer Mustafa
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  3. Jagadeesan Vijay Baskar
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  4. Joseph Rosentel
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  5. S. Theodore Chester
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  6. Martin Knaus
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Correspondence to Martin Knaus.

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This document is provided for scientific purposes only. Any reference to a brand or trademark herein is for informational purposes only and is not intended for a commercial purpose or to dilute the rights of the respective owner(s) of the brand(s) or trademark(s).

Conflict of interest

The work reported herein was funded by Merial Inc., GA, USA. All authors are current employees or collaborators of Merial.

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®Broadline is a trademark of Merial

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Schuster, R.K., Mustafa, M.B., Baskar, J.V. et al. Efficacy of a topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel (Broadline®) against naturally acquired infections with cestodes of the genus Joyeuxiella in cats. Parasitol Res 115, 2679–2684 (2016). https://doi.org/10.1007/s00436-016-5016-3

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