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Advanced schistosomiasis reappeared after curing seemingly being cured for over 20 years and without known history of reexposure to Schistosoma japonicum

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Abstract

Schistosomiasis is an intravascular disease caused by parasitic trematode worms of the genus Schistosoma. It is estimated that more than 200 million people are infected in the world, and 800 million are at risk of infection. The main lesions are due to eggs trapping in tissue which can lead a series of pathogenic effect relative to immune response. Therefore, killing and eradicating eggs in tissue is often the target to treat schistosomiasis. Here, we report 75 patients who being cured for over 20 years developed into advanced schistosomiasis. A total of 90 patients with a diagnosis of schistosomiasis in various periods were enrolled. Of them, all patients have liver fibrosis, splenectomy was performed in 48.0 %, 42.7 % have splenomegaly, and 30.0 % have portal hypertension. No patients were infected with HBV. Moreover, all patients have not been to Schistosoma-endemic regions. Our results showed that there are other factors leading to schistosomiasis progress besides eggs as well as Schistosoma mansoni.

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Acknowledgments

This study is supported by the Jiangsu Provincial Special Fund for Clinical Medicine (No. BL2014020) and the Jiangsu Provincial Commission of Health and Family Planning Applied Fund for Preventing Parasite (X201104).

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    Authors and Affiliations

    1. Jiangsu Institute of Parasitic Diseases, Wuxi, China

      Haiyong Hua

    2. Changshu City Center for Disease Control and Prevention, Changshu, China

      Anhua Yin, Minhao Xu & Zhengyuan Zhou

    3. Nanjing Medical University, Nanjing, China

      Lu You

    4. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China

      Hongxiong Guo

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    1. Haiyong Hua
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    2. Anhua Yin
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    3. Minhao Xu
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    4. Zhengyuan Zhou
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    5. Lu You
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    6. Hongxiong Guo
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    Corresponding author

    Correspondence to Hongxiong Guo.

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    Haiyong Hua and Anhua Yin contributed equally to this work.

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    Hua, H., Yin, A., Xu, M. et al. Advanced schistosomiasis reappeared after curing seemingly being cured for over 20 years and without known history of reexposure to Schistosoma japonicum . Parasitol Res 114, 3535–3538 (2015). https://doi.org/10.1007/s00436-015-4616-7

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    • DOI: https://doi.org/10.1007/s00436-015-4616-7

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