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The main factors influencing canine demodicosis treatment outcome and determination of optimal therapy

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Abstract

The main idea of this research was to evaluate the efficacy of canine demodicosis conventional treatments using mathematical analyses. All available papers published between 1980 and 2014 were used in this study. One hundred six clinical trials enrolling 3414 cases of generalized demodicosis in dogs are studied. Dogs entered in the analysis were only the ones in which the disease occurred naturally, excluding the studies in which transplantation of Demodex canis mites was done from other animals. In conventional acaricide treatments, sorted according to active substances (moxidectin, amitraz, doramectin, ivermectin, and milbemycin oxime), the way of application (spot-on, dips, orally, or subcutaneous), concentration, and interval of application were used as input parameters in mathematical modeling. Data of interest were the treatment outcome, the number of dogs that went into remission, the number of animals not responding to treatment microscopically, the average duration of therapy, the follow-up period, the number of patients with disease recurrence, the number of adverse effects, and the number of animals with side effects. Dogs lost to follow-up or when the treatment was discontinued, due to various reasons not in connection with the therapy protocol, were not considered. Statistical and mathematical analyses were applied for prediction of the drugs’ effectiveness. Developed mathematical models showed satisfactorily r 2, higher than 0.87. Good evidence for recommending the use of milbemycin oxime PO (0.5 mg/kg, daily) and moxidectin spot-on (Advocate®, Bayer) weekly is found. A bit less effective therapies were based on ivermectin PO (0.5 mg/kg, daily), moxidectin PO (0.35 mg/kg, daily), and amitraz dips (0.05 % solution, weekly), respectively. It is important to keep in mind that Advocate® is recommended by the manufacturer for use in milder cases.

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References

  • Antman EM, Lau J, Kupelnick B, Mosteller F, Chalmers TC (1992) A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction. JAMA 268:240–248

    Article  CAS  PubMed  Google Scholar 

  • Arsenović M, Pezo L, Stanković S et al (2013a) Sensitivity analysis of mathematical models for final product properties: link to DTG curve. Ceram Int 39:6277–6285

    Article  Google Scholar 

  • Arsenović M, Stanković S, Radojević Z, Pezo L (2013b) Prediction and fuzzy synthetic optimization of process parameters in heavy clay brick production. Ceram Int 39:2013–2022

    Article  Google Scholar 

  • Basano FS, Kramer L, Gilallicchio B, Genchi C (1999) Impiego della milbemicina ossima nel trattamento della rogna demodettica generalizzata del cane. Veterinaria 13(1):89–93

  • Bastianoni S, Pulselli FM, Focardi S, Tiezzi EBP, Gramatica P (2008) Correlations and complementarities in data and methods through principal components analysis (PCA) applied to the results of the SPIn-Eco Project. J Environ Manag 86(2):419–426

    Article  Google Scholar 

  • Bensignor E, Carlotti D (1998) Moxidectine in the treatment of generalized demodicosis in dogs. A pilot study: 8 cases. In: Kwochka KW, Willemse T, Von Tscharner C (eds) Advances in Veterinary Dermatology. Butterworth-Heinemann, Oxford, pp 554–555

    Google Scholar 

  • Box GEP, Behnken DW (1960) Some new three level designs for the study of quantitative variables. Technometrics 2:455–475

    Article  Google Scholar 

  • Brlek T, Pezo L, Voća N, Krička T, Vukmirović Đ, Čolović R, Bodroža-Solarov M (2013) Chemometric approach for assessing the quality of olive cake pellets. Fuel Process Technol 116:250–256

    Article  CAS  Google Scholar 

  • Burrows A (1997) Evaluation of the clinical efficacy of two different doses of moxidectin in the treatment of generalized demodicosis in the dog. In: Proceedings of the Science Meeting of the Australian College of Veterinary Scientists Sydney. American Academy of Veterinary Dermatology/American College of Veterinary Dermatology, Sydney, 1997

  • Carlotti DN, Bourdeau P, Guaguere E, et al (1998) Therapy of generalized demodicosis with variable oral doses of milbemycin oxime in 88 dogs. In: Kwochka KW, Willemse T, Von Tscharner C (eds), Advances in Veterinary Dermatology. Butterworth-Heinemann, Oxford, pp. 554–555

  • Chen C (1995) A short-tailed demodectic mite and Demodex canis infestation in a Chihuahua dog. Vet Dermatol 6:227–229

    Article  Google Scholar 

  • Das SS (1993) Efficacy of Pestoban aerosol spray in treatment of canine demodicosis. J Vet Parasitol 7:67–69

    Google Scholar 

  • Delayte EH, Otsuka M, Larsson CE, Castro RCC (2006) Eficácia das lactonas macrocíclicas sistêmicas (ivermectina e moxidectina) na terapia da demodicidose canina generalizada. Arq Bras Med Vet Zootec 58(1):31–38

    Article  CAS  Google Scholar 

  • Farmer H, Seawright AA (1980) The use of amitraz (N1-(2,4-dimethylphenyl)-N-[(2,4-dimethylphenyl)imino)-methyl]-N-methylmethanimidamide) in demodecosis in dogs. Aust Vet J 56:537–541

    Article  CAS  PubMed  Google Scholar 

  • Figueiredo C, Viana JA, Curi PR (1993) Clinical evaluation of the effect of vitamin E in the treatment of generalized canine demodicosis. In: Ihrke PJ, Mason IS, White SD (eds) Advances in Veterinary Dermatology. Pergamon Press, Oxford, pp 247–261

    Google Scholar 

  • Fisher MA, Shanks DJ (2008) A review of the off-label use of selamectin (Stronghold®/Revolution®) in dogs and cats. Acta Vet Scand 50:46–50

    Article  PubMed Central  PubMed  Google Scholar 

  • Folz SD, Kakuk TJ, Henke CL, Rector DL, Tesar FB (1984a) Clinical evaluation of amitraz as a treatment for canine demodicosis. Vet Parasitol 16:335–341

    Article  CAS  PubMed  Google Scholar 

  • Folz SD, Kratzer DD, Nowakowaki LH, Conklin RD Jr., Rector DL (1984/85) Evaluation of a topical treatment, alone and in combination with a detergent, for generalized demodicosis. Vet Parasitol 17:165–172

  • Fondati A (1996) Efficacy of daily oral ivermectin in the treatment of 10 cases of generalized demodicosis in adult dogs. Vet Dermatol 7:99–104

    Article  Google Scholar 

  • Fourie LJ, Kok DJ, Du Plessis A, Rugg D (2007) Efficacy of a novel formulation of metaflumizone plus amitraz for the treatment of demodectic mange in dogs. Vet Parasitol 150:268–274

    Article  CAS  PubMed  Google Scholar 

  • Fourie JJ, Delport PC, Fourie LJ, Heine J, Horak IG, Krieger KJ (2009) Comparative efficacy and safety of two treatment regimens with a topically applied combination of imidacloprid and moxidectin (Advocate®) against generalised demodicosis in dogs. Parasitol Res 105:115–124

    Article  Google Scholar 

  • Fourie J, Dumont P, Halos L, Beugnet F, Pollmeier M (2013) Efficacy of a topical application of Certifect® (fipronil 6.26 % w/v, amitraz 7.48 % w/v, (S)-methoprene 5.63 % w/v) for the treatment of canine generalized demodicosis. Parasite. doi:10.1051/parasite/2013046

    Google Scholar 

  • Franc M, Soubeyroux H (1986) Le traitement de la démodécie du chien par un collier a 9% d’amitraz. Rev Med Vet 137:583–586

    Google Scholar 

  • Fukahori FLP (2013) Eficácia do uso de moxidectina por via oral no tratamento de demodicose generalizada em cães: breve relato de dois casos. Med Vet 7(1):31–34

    Google Scholar 

  • Garfield RA, Reedy LM (1992) The use of oral milbemycin oxime (Interceptor) in the treatment of chronic generalized canine demodicosis. Vet Dermatol 3:231–235

    Article  Google Scholar 

  • Genchi C, Genchi M, Petry G (2013) Evaluation of the efficacy of imidacloprid 10 %/moxidectin 2.5 % (Advocate®, Advantage® Multi, Bayer) for the prevention of Dirofilaria repens infection in dogs. Parasitol Res 112:S81–S89

    Article  Google Scholar 

  • Guaguere E (1996) Traitement de la démodécie généralisés du chien par l’ivermectine: a propos de 20 cas. Prat Med Chir Anim Comp 31:33–40

  • Guaguere E (1998) Efficacy of daily oral ivermectin treatment in 38 dogs with generalized demodicosis: a study of relapse rates. In: Kwochka KW, Willemse T, Von Tscharner C (eds) Advances in Veterinary Dermatology. Butterworth Heinemann, Oxford, pp 453–454

    Google Scholar 

  • Hamann F, Wedell H, Bauer J (1997) Zur Demodikose des Hundes. Kleintierpraxis 42:745–754

    Google Scholar 

  • Harbord RM, Egger M, Sterne JA (2006) A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med 25:3443–3457

    Article  PubMed  Google Scholar 

  • Heine J, Krieger K, Dumont P, Hellmann K (2005) Evaluation of the efficacy and safety of imidacloprid 10 % plus moxidectin 2.5 % spot-on in the treatment of generalized demodicosis in dogs: results of a European field study. Parasitol Res 97:S89–S96

    Article  PubMed  Google Scholar 

  • Hellmann K, Heine J, Braun G, Paran-Dobesova R, Svobodova V (2011) Evaluation of the therapeutic and preventive efficacy of 2.5 % moxidectin/10 % imidacloprid (Advocate®, Bayer Animal Health) in dogs naturally infected or at risk of natural infection by Dirofilaria repens. Parasitol Res 109(1):77–86

    Article  Google Scholar 

  • Hillier A, Desch CE (2002) Large-bodied Demodex mite infestation in 4 dogs. J Am Vet Med Assoc 220:623–627

    Article  PubMed  Google Scholar 

  • Hogben D (1968) The distribution of the sample correlation coefficient with one variable fixed. J Res Nat Bur Stand, Sect B 72B(1), available online http://nvlpubs.nist.gov/nistpubs/jres/72B/jresv72Bn1p33_A1b.pdf

  • Holm B (1998) Clinical efficacy of milbemycin oxime in the treatment of canine generalized demodicosis in the dog. A retrospective study of 40 cases (1993–1995). In: Kwochka KW, Willemse T, Von Tscharner C (eds) dvances in Veterinary Dermatology. Butterworth Heinemann, Oxford, pp 582–583

    Google Scholar 

  • Holm BR (2003) Efficacy of milbemycin oxime in the treatment of canine generalized demodicosis: a retrospective study of 99 dogs (1995–2000). Vet Dermatol 14:189–195

    Article  PubMed  Google Scholar 

  • Huang HP, Lien YH (2013) Treatment of canine generalized demodicosis associated with hyperadrenocorticism with spot-on moxidectin and imidacloprid. Acta Vet Scand 55:40

    Article  PubMed Central  PubMed  Google Scholar 

  • Hugnet C, Bruchon-Hugnet C, Royer H, Bourdoiseau G (2001) Efficacy of 1.25 % amitraz solution in the treatment of generalized demodicosis (eight cases) and sarcoptic mange (five cases) in dogs. Vet Dermatol 12:89–92

    Article  CAS  PubMed  Google Scholar 

  • Johnstone IP (2002) Doramectin as a treatment for canine and feline demodicosis. Aust Vet Pract 32:98–103

    Google Scholar 

  • Kamboj DS, Singh KB, Singh A, Mohan R, Nauriyal DC (1993) Studies on the therapeutic efficacy of amitraz, deltamethrin and ivermectin on canine demodicosis. Indian Vet J 70:61–64

    Google Scholar 

  • Karakumi MC, Ural K, Cingi CC, Guzel M, Haydardedeoglu AE, Borku MK (2007) Evaluation of ivermectin tablets in the treatment of generalized canine demodicosis. Rev Méd Vét 158(7):380–383

    Google Scholar 

  • Katoch R, Yadav A, Vohra S, Khajuria JK (nd) Recent trends in herbal ectoparasitical drugs. Winter school lecture, available online: http://www.hillagric.ac.in/edu/covas/vpharma/winter%20school/lectures/37%20herbal%20ectoparasiticidal%20drugs.pdf

  • Khan KS, Kunz R, Kleijnen J, Antes G (2003) Five steps to conducting a systematic review. J R Soc Med 96(3):118–121

    Article  PubMed Central  PubMed  Google Scholar 

  • Kleijnen JPC (2008) Design and analysis of simulation experiments, International Series in Operations Research and Management Science. Springer, Berlin

    Google Scholar 

  • Kuznetsova E, Bettenay S, Nikolaeva L, Majzoub M, Mueller R (2012) Influence of systemic antibiotics on the treatment of dogs with generalized demodicosis. Vet Parasitol 188:148–155

    Article  CAS  PubMed  Google Scholar 

  • Lee H-H, Terada M (1992) In vitro effects of milbemysin oxime: mechanism of action against Angiostrongylus cantonensis and Dirofilaria immitis. Parasitol Res 78:349–353

    Article  CAS  PubMed  Google Scholar 

  • Medleau L, Willemse T (1995a) Efficacy of daily amitraz therapy for refractory, generalized demodicosis in dogs: two independent studies. J Am Anim Hosp Assoc 31:246–249

    Article  CAS  PubMed  Google Scholar 

  • Medleau L, Willemse T (1995b) Efficacy of daily amitraz on generalised demodicosis in dogs. J Small Anim Pract 36(1):3–6

    Article  CAS  PubMed  Google Scholar 

  • Medleau L, Ristić Z, Mcelveen DR (1996) Daily ivermectin for treatment of generalized demodicosis in dogs. Vet Dermatol 7:209–212

    Article  Google Scholar 

  • Meyer D (2008) Therapie der caninen generalisierten demodikose mit einem moxidectin-imidacloprid- spot-on (Advocate®, Bayer), Inaugural-Dissertation, Tierärztlichen fakultät der ludwig-maximilians-universität München, http://edoc.ub.uni-muenchen.de/9543/1/Meyer_Daniela.pdf

  • Miller WH Jr, Scott DW, Wellington JR, Panić R (1993) Clinical efficacy of milbemycin oxime in the treatment of generalized demodicosis in adult dogs. J Am Vet Med Assoc 203(10):1426–1429

    PubMed  Google Scholar 

  • Miller WH Jr, Scott DW, Cayatte SM, Buerger RG, Bagladi MS (1995) Clinical efficacy of increased dosages of milbemycin oxime for treatment of generalized demodicosis in adult dogs. J Am Vet Med Assoc 207(12):1581–1584

    CAS  PubMed  Google Scholar 

  • Mueller RS (2004) Treatment protocols for demodicosis: an evidence-based review. Vet Dermatol 15:75–89

    Article  PubMed  Google Scholar 

  • Mueller RS (2011) Evidence-based treatment of canine demodicosis. Tierarztl Prax Ausg K Kleintiere Heimtiere 39(6):419–424

    CAS  PubMed  Google Scholar 

  • Mueller RS, Bettenay SV (1995) Milbemycin oxime in the treatment of canine demodicosis. Aust Vet Pract 25:122–126

    Google Scholar 

  • Mueller RS, Hastie K, Bettenay SV (1999) Daily oral ivermectin for the treatment of generalised demodicosis in 23 dogs. Aust Vet Pract 29:132–136

    Google Scholar 

  • Mueller RS, Meyer D, Bensignor E, Sauter-Louis C (2009) Treatment of canine generalized demodicosis with a ‘spot-on’ formulation containing 10 % moxidectin and 2.5 % imidacloprid (Advocate®, Bayer Healthcare). Vet Dermatol 20:441–446

    Article  PubMed  Google Scholar 

  • Muller GH (1983) Amitraz treatment of demodicosis. J Am Anim Hosp Assoc 19:435–441

    Google Scholar 

  • Murayama N, Shibata K, Nagata M (2010) Efficacy of weekly oral doramectin treatment in canine demodicosis. Vet Rec 167:63–64

    Article  CAS  PubMed  Google Scholar 

  • Nourani V, Fard MS (2012) Sensitivity analysis of the artificial neural network outputs in simulation of the evaporation process at different climatologic regimes. Adv Eng Softw 47:127–146

    Article  Google Scholar 

  • Otto M (1999) Chemometrics statistics and computer application in analytical chemistry. Wiley-VCH, Weinheim

    Google Scholar 

  • Paradis M (1999) New approaches to the treatment of canine demodicosis. Vet Clin N Am Small 29(6):1425–1436

    Article  CAS  Google Scholar 

  • Paradis M, Laperriere E (1992) Efficacy of daily ivermectin treatment in a dog with amitraz-resistant, generalized demodicosis. Vet Dermatol 3(2):85–88

    Article  Google Scholar 

  • Paradis M, Pag N (1998) Topical (pour-on) ivermectin in the treatment of chronic generalized demodicosis in dogs. Vet Dermatol 9:55–59

    Article  Google Scholar 

  • Paradis M, Ristic Z (1993) Efficacy of daily ivermectin in dogs with generalized demodicosis. In: Proceedings of the 10th ESVD (European Society of Veterinary Dermatology) annual congress. Aalborg, Denmark, Published by European Society of Veterinary Dermatology, pp 59–60

  • Paterson TE, Halliwell RE, Fields PJ, Louw ML, Louw JP, Ball GS, Pinckney RD, McKibben JS (2009) Treatment of canine-generalized demodicosis: a blind, randomized clinical trial comparing the efficacy of Advocate® R (Bayer Animal Health) with ivermectin. Vet Dermatol 20:447–455

    Article  PubMed  Google Scholar 

  • Paul AJ, Tranquilli WJ, Seward R et al (1987) Clinical observations in Collies given ivermectin orally. Am J Vet Res 48:684–685

    CAS  PubMed  Google Scholar 

  • Pekmezci D, Pekmezci GZ, Guzel M, Cenesiz S, Gurler AT, Gokalp G (2014) Efficacy of amitraz plus inactivated parapoxvirus ovis in the treatment of canine generalized demodicosis. Vet Rec 174:556

    Article  CAS  PubMed  Google Scholar 

  • Prior RL, Wu X, Schaich K (2005) Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. J Agric Food Chem 53(10):4290–4302

    Article  CAS  PubMed  Google Scholar 

  • Prisma statement. http://www.prisma-statement.org/

  • Ristic Z, Medleau L, Paradis M, White-Weithers NE (1995) Ivermectin for treatment of generalized demodicosis in dogs. J Am Vet Med Assoc 207(10):1308–1310

    CAS  PubMed  Google Scholar 

  • Roy S, Ghosh RC, Sen SK (1992) Therapeutic evaluation of amitraz against canine demodicosis. Indian Vet J 69:750–751

    Google Scholar 

  • Saridomichelakis M, Koutinas A, Papadogiannakis E, Papazachariadou M, Liapi M, Trakas D (1999) Adult-onset demodicosis in two dogs due to Demodex canis and a short-tailed demodectic mite. J Small Anim Pract 40:529–532

    Article  CAS  PubMed  Google Scholar 

  • Scott DW, Walton DK (1985) Experiences with the use of amitraz and ivermectin for the treatment of generalized demodicosis in dogs. J Am Anim Hosp Assoc 21:535–541

    Google Scholar 

  • Singh SK, Kumar M, Jadhav RK, Saxena SK (2011) An update on therapeutic management of canine demodicosis. Vet World 4(1):41–44

    Article  Google Scholar 

  • Sushma C, Khahra SS, Nauriyal DC et al (2001) Efficacy of ivermectin and moxidectin in treatment of ectoparasitic infestation in dogs. Indian J Vet Med 21:91–92

    Google Scholar 

  • Tapp T, Muse R, Rosenkrantz WS (1998) Efficacy of alternate day oral ivermectin in the treatment of generalized demodicosis. Proceedings of the 14th Annual Meeting of the American Academy of Veterinary Dermatology/American College Of Veterinary Dermatology San Antonio. Australian College of Veterinary Scientists, Sydney, p 25

    Google Scholar 

  • Tarallo VD, Lia RP, Sasanelli M, Cafarchia C, Otranto D (2009) Efficacy of amitraz plus metaflumizone for the treatment of canine demodicosis associated with malassezia pachydermatis. Parasite Vector 2:13

    Article  Google Scholar 

  • Turanzi T, Tomlin AS (2014) Analysis of Kinetics Reaction Mechanisms, Springer/Verlag, Berlin Heidelberg

  • Unsworth K (1946) Studies on the clinical and parasitological aspects of canine demodectic mange. J Comp Pathol 56:114–127

    Article  CAS  Google Scholar 

  • Wagner R, Wendlberger U (2000) Field efficacy of moxidectin in dogs and rabbits naturally infested with Sarcoptes spp., Demodex spp. and Psoroptes spp. mites. Vet Parasitol 93:149–158

    Article  CAS  PubMed  Google Scholar 

  • Živičnjak T (2005) A retrospective evaluation of efficiency in therapy for generalized canine demodicosis. Vet Arhiv 75(4):303–310

    Google Scholar 

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Authors and Affiliations

  1. IMS Institute, Bulevar vojvode Mišića 43, 11000, Belgrade, Serbia

    Milica Arsenović

  2. Institute of General and Physical Chemistry, University of Belgrade, Studentski trg 12, 11000, Belgrade, Serbia

    Lato Pezo

  3. Veterinary Clinic Spina, Bulevar Arsenija Čarnojevića 17a, 11000, Belgrade, Serbia

    Nebojša Vasić & Rodoljub Ćirić

  4. Noble Veterinary Clinic, The Market-Green Community, Dubai Investment Park, 213372, Dubai, United Arab Emirates

    Milan Stefanović

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Arsenović, M., Pezo, L., Vasić, N. et al. The main factors influencing canine demodicosis treatment outcome and determination of optimal therapy. Parasitol Res 114, 2415–2426 (2015). https://doi.org/10.1007/s00436-015-4543-7

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