Efficacy of Emodepside/Praziquantel Spot-on (Profender®) against adult Aelurostrongylus abstrusus Nematodes in Experimentally Infected Cats
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The adulticidal efficacy of a topical combination of emodepside 2.1 % (w/v) plus praziquantel 8.6 % (w/v) (Profender® spot-on for cats, Bayer) against adult Aelurostrongylus abstrusus nematodes was evaluated in two randomised, placebo-controlled laboratory efficacy studies. Each study involved 16 cats experimentally inoculated with L3 (800 and 600 each in studies no. 1 and 2, respectively) and randomised into two study groups of 8 cats each after onset of patency. While cats in the treatment group in study no. 1 received a single spot-on application at the minimum therapeutic dose (3 mg/kg emodepside and 12 mg/kg praziquantel), cats in study no. 2 were treated twice with an interval of 14 days. The faecal output of first stage larvae was monitored throughout the study. Necropsy was conducted 4 or 5 weeks after the (first) treatment and the worm counts were used for efficacy calculations. The control groups showed a geometric mean of the total worm count (live and dead worms) of 28.8 (study no. 1) and 17.6 (study no. 2), respectively. All control animals were infected. While the single treatment in study no. 1 resulted in a reduction of the total worm burden by 73.0 % (p = 0.0070), the treatment protocol in study no. 2 was 99.2 % effective (p = 0.0035). Based on live worm counts, the efficacy in study no. 2 was 100 % (p = 0.0030). It is concluded that two applications of Profender® spot-on given two weeks apart represent a safe and highly efficacious treatment regime against feline aelurostrongylosis.
KeywordsPraziquantel Emodepside Faecal Examination Fenbendazole Worm Count
- Baermann G (1917) Eine einfache Methode zur Auffindung von Ankylostomum-(Nematoden)-Larven in Erdproben. Tijdschr Diergeneesk 57:131–137Google Scholar
- Brianti E, Gaglio G, Giannetto S, Annoscia G, Latrofa MS, Dantas-Torres F, Traversa D, Otranto D (2012) Troglostrongylus brevior and Troglostrongylus subcrenatus (Strongylida: Crenosomatidae) as agents of broncho-pulmonary infestation in domestic cats. Parasit Vectors 5:178. doi: 10.1186/1756-3305-5-178 PubMedCentralPubMedCrossRefGoogle Scholar
- Di Cesare A, Di Francesco G, Frangipane di Regalbono A, Eleni C, De Liberato C, Marruchella G, Iorio R, Malatesta D, Romanucci MR, Bongiovanni L, Cassini R, Traversa D (2015a) Retrospective study on the occurrence of the feline lungworms Aelurostrongylus abstrusus and Troglostrongylus spp. in endemic areas of Italy. Vet J 203:233–238PubMedCrossRefGoogle Scholar
- Hobmaier M, Hobmaier A (1935b) Mammalian phase of the lungworm Aelurostrongylus abstrusus in the cat. J Am Vet Med Assoc 87:191–198Google Scholar
- Norsworthy GD (2011) Lung parasites. In: Norsworthy GD, Grace SF, Crystal MA, Tilley LP (eds) The feline patient. 4th edn. John Wiley & Sons, eBook, chapter 129Google Scholar
- Reinhardt S, Ottenjann M, Schunack B, Kohn B (2004) Lungenwurmbefall (Aelurostrongylus abstrusus) bei einer Katze. Kleintierpraxis 49:239–246Google Scholar
- Schmid K, Duewel D (1990) Use of fenbendazole (Panacur® tablets ad. us. vet.) against helminth infections in cats. Tieraerztl Umsch 45:873–875Google Scholar
- VICH Guideline 7: Efficacy of Anthelmintics: General Requirements. Veterinary International Cooperation on Harmonization, European Agency for the Evaluation of Medicinal Products, London, CVMP/VICH/832/99-corr, November 2000Google Scholar
- VICH Guideline 9: Good Clinical Practice. Veterinary International Cooperation on Harmonization, European Agency for the Evaluation of Medicinal Products, London, CVMP/VICH/595/98-Final, June 2000Google Scholar
- VICH Guideline 20: Efficacy of Anthelmintics: Specific Recommendations for Felines. Veterinary International Cooperation on Harmonization, European Agency for the Evaluation of Medicinal Products, London, CVMP/VICH/545/00-Final, June 2001Google Scholar
- Vig MM, Murray PA (1986) Successful tretment of Aelurostrongylus abstrusus with fenbendazole. Comp Cont Educ Pract Vet 8:214–222Google Scholar
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