Abstract
Speed of kill, repellent (anti-feeding) and acaricidal efficacy of an imidacloprid 10 % (w/w) /flumethrin 4.5 % (w/w) collar (Seresto®, Bayer) and a spot-on formulation of fipronil 8.3 % (w/v) /(S)-methoprene 10 % (w/v) /eprinomectin 0.4 % (w/v) /praziquantel 8.3 % (w/v) (Broadline®, Merial) against artificiallyinduced infestations with Ixodes ricinus on cats, were assessed in a parallel group design, randomised, controlled study. Twenty-four cats were included and randomly allocated to treatment groups or a non-treated control group. Starting on Day (D) 7 after treatment until D28, cats were each infested with 50 I. ricinus at weekly intervals. Ticks were counted in situ on the cats at 6, 12 and 24 h and upon removal 48 h after each infestation. Based on arithmetic means, Seresto® proved to be 100 % effective against adult I. ricinus at all assessment times (6, 12, 24 and 48 h after infestation) throughout the month-long study. Broadline® was 0 % to 16.7 % effective at 6 h, 26.8 % to 50.0 % effective at 12 h, while at 24 h after infestation efficacy peaked at 81.5 % on D15 declining to 31.5 % on D29. Based on the 48 h tick counts, the efficacy of Broadline® peaked at 100 % on D16 after treatment and decreased to 83.2 % by D30. The Seresto® collar provided significantly faster speed of kill and better persistent acaricidal effectiveness against Ixodes ricinus on cats compared to Broadline® spot-on. The additional repellent (anti-feeding) effect of Seresto® prevents parasites from taking a blood meal and thereby reduces the risk of vector-borne disease pathogen transmission.
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References
Estrada-Peña A, Bouattour A, Camicas J-L, Walker AR (2004) Ticks of domestic animals in the Mediterranean region. University of Zaragoza, Spain
Guglielmone A, Robbins RG, Apanaskevich DA, Petney TN, Estrada-Peña A, Horak IG (2014) The hard ticks of the world (Acari: Ixodida: Ixodidae). Springer, Dordrecht, Heidelberg
Halos L, Baneth G, Beugnet F, Bowman AS, Chomel B, Farkas R, Franc M, Guillot J, Inokuma H, Kaufman R, Jongejan F, Joachim A, Otranto D, Pfister K, Pollmeier M, Sainz A, Wall R (2011) Defining the concept of ‘tick repellency’ in veterinary medicine. Parasitology 139(4):419–423
Knaus M, Abu-Madi MA, Ibarra-Velarde F, Kok DJ, Kusi I, Postoli R, Chester ST, Rosentel J, Alva R, Irwin J, Visser M, Winter R, Rehbein S (2014) Efficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination against naturally acquired intestinal nematode and cestode infections in cats. Vet Parasitol 202:18–25
Kvaternick V, Kellermann M, Knaus M, Rehbein S, Rosentel J (2014) Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel. Vet Parasitol 202:2–9
Lindgren E, Tälleklint L, Polfeldt T (2000) Impact of climatic change on the northern latitude limit and population density of the disease-transmitting European tick Ixodes ricinus. Environ Health Perspect 108:119–123
Marchiondo AA, Holdsworth PA, Fourie LJ, Rugg D, Hellmann K, Snyder DE, Dryden MW (2013) World Association for the Advancement of Veterinary Parasitology (WAAVP) second edition: guidelines for evaluating the efficacy of parasiticides for the treatment, prevention and control of flea and tick infestations on dogs and cats. Vet Parasitol 194:84–97
Ogden NH, Cripps P, Davison CC, Owen G, Parry JM, Timms BJ, Forbes AB (2000) The ixodid tick species attaching to domestic dogs and cats in Great Britain and Ireland. Med Vet Entomol 14:332–338
Reichard MV, Thomas JE., Arther RG, Hostetler JA, Raetzel KL, Meinkoth JH, SE (2013) Efficacy of an imidacloprid 10 % / flumethrin 4.5 % collar (Seresto®, Bayer) for preventing the transmission of Cytauxzoon felis to domestic cats by Amblyomma americanum. Para Res Volume 112, Issue 1 Supplement, pp 11 – 20
Stanneck D, Kruedewagen EM, Fourie JJ, Horak IG, Davis W, Krieger KJ (2012a) Efficacy of an imidacloprid/flumethrin collar against fleas and ticks on cats. Parasit Vectors 5:82
Stanneck D, Kruedewagen EM, Fourie JJ, Horak IG, Davis W, Krieger KJ (2012b) Evaluation of the long-term efficacy and safety of an imidacloprid 10 %/flumethrin 4.5 % polymer matrix collar (Seresto®) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe. Parasit Vectors 5:66
Tielemans E, Manavella C, Visser M, Chester ST, Rosentel J (2014a) Efficacy in cats of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, praziquantel, against induced infestations of Echinococcus multilocularis. Vet Parasitol 202:26–29
Tielemans E, Prullage J, Knaus M, Visser M, Manavella C, Chester ST, Young D, Everett WR, Rosentel J (2014b) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel, against the ticks, Ixodes ricinus and Ixodes scapularis, on cats. Vet Parasitol 202:59–63
Walker AR, Bouattour A, Camicas J-L, Estrada-Peña A, Horak IG, Latif AA, Pegram RG, Preston P (2003) Ticks of domestic animals in Africa: a guide to identification of species. Bioscience reports, Edinburgh
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Fourie, J.J., Horak, I.G., de Vos, C. et al. Comparative Speed of Kill, Repellent (anti-feeding) and Acaricidal Efficacy of an Imidacloprid/Flumethrin Collar (Seresto®) and a Fipronil/(S)-Methoprene/Eprinomectin/Praziquantel Spot-on (Broadline®) against Ixodes ricinus (Linné, 1758) on Cats. Parasitol Res 114 (Suppl 1), 109–116 (2015). https://doi.org/10.1007/s00436-015-4517-9
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DOI: https://doi.org/10.1007/s00436-015-4517-9