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Efficacy of larvicidal activity of green synthesized titanium dioxide nanoparticles using Mangifera indica extract against blood-feeding parasites

Parasitology Research volume 114, pages 571–581 (2015)Cite this article

Abstract

Titanium dioxide nanoparticles (TiO2 NPs) are considered to be among the best photocatalytic materials due to their long-term thermodynamic stability, strong oxidizing power, and relative non-toxicity. Nano-preparations with TiO2 NPs are currently under investigation as novel treatments for acne vulgaris, recurrent condyloma acuminata, atopic dermatitis, hyperpigmented skin lesions, and other non-dermatologic diseases. The present study was to investigate the acaricidal and larvicidal activity of synthesized TiO2 NPs utilizing leaf aqueous extract of Mangifera indica L. (Anacardiaceae) against hematophagous parasites. The anti-parasitic activity of TiO2 NPs against the larvae of Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Haemaphysalis bispinosa (Acari: Ixodidae), fourth instar larvae of Anopheles subpictus, and Culex quinquefasciatus (Diptera: Culicidae) were assessed. The green synthesized TiO2 NPs were analyzed by UV–Vis, FTIR, X-ray diffraction (XRD), AFM, SEM, and TEM. The XRD analysis of synthesized TiO2 NPs revealed the dominant peak at 2θ value of 27.81 which matched the 110 crystallographic plane of the rutile structure indicating the crystal structure. The FTIR spectra exhibited a prominent peak at 3,448 cm−1 and showed OH stretching due to the alcoholic group, and the OH group may act as a capping agent. The SEM images of TiO2 NPs displayed spherical, oval in shape, individual, and some in aggregates. Characterization of the synthesized TiO2 NPs using AFM offered three-dimensional visualization and uneven surface morphology. The TEM micrograph showed agglomerates, round and slight elongation with an average size of 30 ± 5 nm. The maximum efficacy was observed in synthesized TiO2 NPs against the larvae of R. microplus, Hyalomma anatolicum anatolicum, Haemaphysalis bispinosa, A. subpictus, and Culex quinquefasciatus with LC50 value of 28.56, 33.17, 23.81, 5.84, and 4.34 mg/L, respectively. In the present study, a novel, simple, and eco-friendly approach has been suggested to control blood-feeding parasites.

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Acknowledgments

The authors are grateful to the management of C. Abdul Hakeem College, Principal, and HOD of Zoology for their help and support to carry out the present study.

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Affiliations

  1. Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam, Vellore District, 632 509, Tamil Nadu, India

    Govindasamy Rajakumar, Abdul Abdul Rahuman, Karunanithi Anbarasan & Viswanathan Karthikeyan

  2. Organic & Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632 014, Tamil Nadu, India

    Selvaraj Mohana Roopan

  3. Department of Crop Science, Konkuk University, Seoul, 143-701, South Korea

    Ill-Min Chung

Authors
  1. Govindasamy Rajakumar
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  2. Abdul Abdul Rahuman
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  3. Selvaraj Mohana Roopan
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  4. Ill-Min Chung
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  5. Karunanithi Anbarasan
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  6. Viswanathan Karthikeyan
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Correspondence to Abdul Abdul Rahuman.

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Rajakumar, G., Rahuman, A.A., Roopan, S.M. et al. Efficacy of larvicidal activity of green synthesized titanium dioxide nanoparticles using Mangifera indica extract against blood-feeding parasites. Parasitol Res 114, 571–581 (2015). https://doi.org/10.1007/s00436-014-4219-8

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  • DOI: https://doi.org/10.1007/s00436-014-4219-8

Keywords

  • Larvicidal activity
  • Titanium dioxide nanoparticles
  • Mangifera indica
  • Rhipicephalus (Boophilus) microplus
  • Hyalomma anatolicum anatolicum
  • Haemaphysalis bispinosa
  • Anopheles subpictus
  • Culex quinquefasciatus