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Treatment and control of bovine sarcoptic and psoroptic mange infestation with ivermectin long-acting injectable (IVOMEC® GOLD)

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Abstract

The efficacy of ivermectin long-acting injection (IVM LAI, IVOMEC® GOLD, Merial; 3.15 % ivermectin w/v) formulation was evaluated in cattle with induced Sarcoptes scabiei var. bovis or Psoroptes ovis infestations. A total of 64 cattle were included in this series of four studies, with 16 animals per study. Approximately, 8 weeks following initial induced mite infestation, cattle were allocated to treatment groups based on decreasing pre-treatment bodyweights. Treatments (saline (control) or IVM LAI (630 mcg ivermectin/kg bodyweight) at 1 mL/50 kg bodyweight) were administered by a single subcutaneous injection in front of the right shoulder on Day 0. Skin scrapings were collected prior to treatment and at approximately weekly intervals for 8 weeks thereafter to establish live mite counts. Character and extent of skin lesions were evaluated at each sampling. Animals were weighed before treatment and at the end of the studies. Mite counts of the IVM LAI-treated animals were significantly (p < 0.05) lower than those of the controls in all four studies at all occasions post-treatment. In the two Sarcoptes studies, IVM LAI-treated cattle were free of mites at 14 days after treatment and in the Psoroptes studies at 13 or 28 days post-treatment. All IVM LAI-treated cattle remained free of mites to the end of the studies while all control animals remained infested. Mange lesions of the IVM LAI-treated animals improved significantly (p < 0.05) compared to those of the controls from Day 21 (Sarcoptes studies) and from Days 28 or 34 (Psoroptes studies). In all studies, mean weight gain over the 8 week post-treatment period was significantly (p < 0.05) higher for the IVM LAI-treated animals than for the controls: Sarcoptes studies, 64.1 and 68.6 kg vs. 46.9 and 48.6 kg, respectively; Psoroptes studies, 43.0 and 43.4 kg vs. 20.8 and 34.9 kg, respectively. All animals accepted the treatment well, and no treatment-related health problems and adverse events were observed throughout the studies. These studies demonstrated the high efficacy of IVOMEC® GOLD against sarcoptic and psoroptic mange in cattle.

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Disclaimer

IVOMEC® GOLD is a registered trademark of Merial. All other marks are the property of their respective owners. This document is provided for scientific purposes only. Any reference to a brand or trademark herein is for informational purposes only and is not intended for a commercial purpose or to dilute the rights of the respective owner(s) of the brand(s) or trademark(s).

Conflict of interest

The work reported herein was funded by Merial Limited, GA, USA. All authors are current employees (DH, MV, RW, SY, LC, SR) or were contractors (AJ, ML, KP, CS) of Merial and assisted with the study design, conduct, data analysis, and preparation of the manuscript.

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Author notes

  1. Cornelia Silaghi

    Present address: Institute of Parasitology, Swiss National Centre for Vector Entomology, Vetsuisse Faculty, University of Zürich, Winterthurerstrasse 266a, 8057, Zürich, Switzerland

Authors and Affiliations

  1. Merial GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101, Rohrdorf, Germany

    Dietmar Hamel, Martin Visser, Renate Winter & Steffen Rehbein

  2. Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine, Veterinärplatz 1, 1210, Vienna, Austria

    Anja Joachim

  3. Institute of Pathology and Forensic Veterinary Medicine, Department of Pathobiology, University of Veterinary Medicine, Veterinärplatz 1, 1210, Vienna, Austria

    Michael Löwenstein

  4. Comparative Tropical Medicine and Parasitology, Ludwig-Maximilians-Universität, Leopoldstr. 5, 80802, Munich, Germany

    Kurt Pfister & Cornelia Silaghi

  5. Merial Limited, 3239 Satellite Blvd., Duluth, GA, 30096, USA

    Stephen Yoon & Luiz Cramer

Authors
  1. Dietmar Hamel
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  2. Anja Joachim
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  3. Michael Löwenstein
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  4. Kurt Pfister
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  5. Cornelia Silaghi
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  6. Martin Visser
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  7. Renate Winter
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  9. Luiz Cramer
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  10. Steffen Rehbein
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Correspondence to Dietmar Hamel.

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Hamel, D., Joachim, A., Löwenstein, M. et al. Treatment and control of bovine sarcoptic and psoroptic mange infestation with ivermectin long-acting injectable (IVOMEC® GOLD). Parasitol Res 114, 535–542 (2015). https://doi.org/10.1007/s00436-014-4215-z

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  • DOI: https://doi.org/10.1007/s00436-014-4215-z

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