Skip to main content

Abnormal liver function in different patients with Schistosoma japonicum

Parasitology Research volume 114, pages 85–90 (2015)Cite this article

Abstract

Schistosomiasis japonica, caused by Schistosoma japonicum, is still a serious public health problem in China. It is important for schistosomiasis control to prevent from infection and advanced patients. Recent years, however, the form of the prevalence of schistosomiasis japonica in China was changed these days. Paying attention to the quality of life of these patients already infected with S. japonicum becomes a new objective to schistosomiasis control program. Although most of the chronic infections with S. japonicum will finally appear as liver fibrosis symptoms, it is still unknown liver function abnormalities in patients with severe forms of schistosomiasis, and there is also no evidence whether S. japonicum infection will directly cause damage to liver cells. Thus, this study investigated 494 patients diagnosed with S. japonicum (87.7 %) and 69 healthy subjects from a endemic areas belonging to Jiangxi Province of China and aimed to evaluate the liver function abnormalities in patients with severe forms of schistosomiasis and possible associations with coinfection with HBV. The results showed that the hepatic metabolism situation significantly changed in patients infected with S. japonicum; meanwhile, the abnormal rates of ALT and AST in patients with schistosomiasis were significantly higher than that in the control group, which confirmed that patients infected with S. japonicum not only had damaged liver function but also the hepatic cells were directly influenced. And the coinfection of CHB and schistosomiasis japonica can be a risk factor for more serious outcomes in patients from endemic areas. These results give us the advice that in the further treatment of patients infected with S. japonicum, especially these coinfections, we should better give the routine liver-protection treatment in advance.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  • Al-Hanafi N, Monem F (2014) Hepatitis B splice-generated protein antibodies in Syrian chronic hepatitis B patients: incidence and significance. Hepat Mon 14(4):e13166

    PubMed Central  PubMed  Article  Google Scholar 

  • Andrade ZA (2004) Schistosomal hepatopathy. Mem Inst Oswaldo Cruz 99(suppl I):51–57

  • Bogliolo L (1957) The anatomical picture of the liver in hepatosplenic schistosomiasis mansoni. Ann Trop Med Parasitol 51:1–14

    CAS  PubMed  Google Scholar 

  • Cai WM, Ma YL, Fu BZ (1985) Preliminary investigation on serum markers of hepatitis B virus in patients with schistosomiasis japonica. Chin Med J (Engl) 98(10):717–720

    CAS  Google Scholar 

  • Cai WM, Tao J, Weng HL, Liu RH (2003) Study on the influence factors of the serum fibrosis markers. Chin J Hepatol 11(1):23–25

    Google Scholar 

  • Chen MG (2014) Assessment of morbidity due to Schistosoma japonicum infection in China. Infect Dis Poverty 3(1):6

    PubMed Central  PubMed  Article  Google Scholar 

  • Chen X et al (2014) A description of the hepatitis B virus genomic background in a high-prevalence area in China. Virol J 11(1):101

    PubMed Central  PubMed  Article  Google Scholar 

  • Dang H et al (2014) Monitoring the transmission of Schistosoma japonicum in potential risk regions of China, 2008–2012. Int J Environ Res Public Health 11(2):2278–2287

    PubMed Central  PubMed  Article  Google Scholar 

  • El-Sabah AA, El-Metwally MT, Abozinadah NY (2011) Hepatitis C and B virus in schistosomiasis patients on oral or parenteral treatment. J Egypt Soc Parasitol 41(2):307–314

    PubMed  Google Scholar 

  • Goncalves EM, Campos R, Amato Neto V, Pinta PL, Moreira AA (1988) Use of sodium azide, as feces preservative, for the study of eggs of Schistosoma mansoni by the Kato-Katz method. Rev Soc Bras Med Trop 21(2):55–58

    CAS  PubMed  Article  Google Scholar 

  • Kunika K, Itakura M, Yamashita K (1991) Correction of fructosamine value for serum albumin and globulin concentrations. Diabetes Res Clin Pract 13(1–2):37–44

    CAS  PubMed  Article  Google Scholar 

  • Li Y et al (1993) A study and analysis of the deaths due to advanced Schistosoma japonicum infection in the Dongting Lake area of China. J Trop Med Hyg 96(2):128–130

    CAS  PubMed  Google Scholar 

  • Pereira LM et al (1994) Hepatitis B virus infection in schistosomiasis mansoni. J Med Virol 42(2):203–206

    CAS  PubMed  Article  Google Scholar 

  • Sato M et al (2014) Potential Associations between perihepatic lymph node enlargement and liver fibrosis, hepatocellular injury, or hepatocarcinogenesis in chronic hepatitis b virus infection. Hepatol res: the official journal of the Japan Society of Hepatology

  • St Symmers WC (1904) Note on a new form of liver cirrhosis due to the presence of the ova of Bilharzia haematobia. J Pathol Bacteriol 9:237–239

    Article  Google Scholar 

  • Tao J, Peng HQ, Cai WM, Dong FQ, Weng HL, Liu RH (2003) Influence factors of serum fibrosis markers in liver fibrosis. World J Gastroenterol 9(11):2497–2500

    PubMed  Google Scholar 

  • Xiao L et al (2014) Parameters associated with significant liver histological changes in patients with chronic hepatitis B. ISRN Gastroenterol 2014:913890. doi:10.1155/2014/913890

    PubMed Central  PubMed  Google Scholar 

  • Xie H, Chen D, Luo X, Gao Z, Fang H, Huang J (2013) Some characteristics of IL-5-producing T cells in mouse liver induced by Schistosoma japonicum infection. Parasitol Res 112(5):1945–1951

    PubMed  Article  Google Scholar 

  • Yan F, Zhao J, Ma J, Li Z, Su Q (2003) Metabolic effects of a novel bioartificial liver on serum from severe hepatitis patients: an in vitro study. Chin Med J (Engl) 116(10):1471–1474

    CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the grants from Jiangxi Provincial Science and Technology Support Project (No. 2011WBBG7001) and the National Natural Science Foundation of China (No. 30972574 and 81201309) and a grant from the China Postdoctoral Science Foundation (No. 2011 M501363), the Natural Science Foundation of Guangdong Province, China (No. 3S2012040007256), and Foundation of Doctoral Program of Higher Education of China (No.20120171120049).

Conflict of interest

The authors declare that they have no conflicts of interest.

Author information

Affiliations

  1. Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, China

    An Ning, Hongyu Li, Zulu Gao, Jun Xu & Fei Hu

  2. Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China

    Xiaoying Wu

  3. Key Laboratory of Tropical Diseases and Control of the Ministry of Education, Guangzhou, China

    Jinyi Liang, Jia Shen, Zhen Liu, Feng Wu, Pengyu Ji, Zhongdao Wu & Xi Sun

  4. Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People’s Republic of China

    Jinyi Liang, Jia Shen, Zhen Liu, Feng Wu, Pengyu Ji, Zhongdao Wu & Xi Sun

Authors
  1. An Ning
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaoying Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hongyu Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jinyi Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zulu Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jia Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zhen Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jun Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Fei Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Feng Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Pengyu Ji
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Zhongdao Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Xi Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xi Sun.

Additional information

An Ning and Xiaoying Wu contributed equally to this work.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Ning, A., Wu, X., Li, H. et al. Abnormal liver function in different patients with Schistosoma japonicum . Parasitol Res 114, 85–90 (2015). https://doi.org/10.1007/s00436-014-4163-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00436-014-4163-7

Keywords

  • Schistosomiasis japonica
  • Liver function
  • Abnormal