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Animal model of human disease with optic neuritis: neuropapillitis in a rat model infected with Angiostrongylus cantonensis

Parasitology Research volume 113, pages 4005–4013 (2014)Cite this article

Abstract

Human Angiostrongylus cantonensis (A. cantonensis) is a food-borne parasitic disease and can cause optic neuritis. Increasing clinical angiostrongyliasis cases with optic neuritis have been reported, but the pathogenesis has not been fully understood until now. Here, we applied rats with A. cantonensis infection as an animal model to study the pathogenesis of optic neuritis caused by the infection. We observed that the optic disk of experimental rats appeared hyperemic, the retina vein became thick, and the visual evoked potential (VEP) latency was prolonged. There were obvious inflammatory cell infiltration in the retina and optic nerve adventitia followed with obvious optic nerve fiber demyelination and retina ganglion swelling. We also evaluated the effect of dexamethasone combined with albendazole on optic neuritis of rats infected with A. cantonensis. The results showed it had no obvious effect to prevent progressive visual deterioration for optic neuritis caused by A. cantonensis. The studies provided evidence that the pathogenesis of optic neuritis in infected rats was correlated to optic nerve demyelination and ganglion cell damage caused by optic nerve inflammation, and the common therapy to this disease was not so effective. Based on the above results, it may be necessary to combine neuroprotective agents with common therapy to treat and protect optic nerve and ganglion cells from their secondary injury.

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Acknowledgments

The authors would like to thank Zhongshan Ophthalmic Center, Sun Yat-sen University, for providing the apparatus for ophthalmologic examination of this article. This work was supported in part by the National Natural Science Foundation of China (No. 81261160324 and No. 81271855) “973” project (No. 2010CB530000) of China and The PhD Start-up Fund of Natural Science Foundation of Guangdong Province of China (No. 4203021) grant.

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Affiliations

  1. Department of Parasite, Zhongshan School of Medicine, Sun Yat-sen University, 74# Zhongshan 2nd Road, Guangzhou, 510080, China

    Ying Feng, Xin Zeng, Li-si Ou-Yang, Xi Sun & Zhong-Dao Wu

  2. Key Laboratory of Tropical Disease Control (SYSU), Ministry of Education, Guangzhou, 510080, China

    Xin Zeng, Xi Sun, Zhiyue Lv & Zhong-Dao Wu

  3. Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510080, China

    Wei-hua Li & Wen-cong Wang

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  1. Ying Feng
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  2. Xin Zeng
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  3. Wei-hua Li
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  4. Wen-cong Wang
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  5. Li-si Ou-Yang
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  6. Xi Sun
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  7. Zhiyue Lv
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  8. Zhong-Dao Wu
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Correspondence to Zhong-Dao Wu.

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Feng, Y., Zeng, X., Li, Wh. et al. Animal model of human disease with optic neuritis: neuropapillitis in a rat model infected with Angiostrongylus cantonensis . Parasitol Res 113, 4005–4013 (2014). https://doi.org/10.1007/s00436-014-4067-6

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  • DOI: https://doi.org/10.1007/s00436-014-4067-6

Keywords

  • Angiostrongylus cantonensis
  • Optic neuritis
  • Rat
  • Therapeutic effect