Abstract
Calodium hepaticum (syn. Capillaria hepatica) and Calodium splenaecum (syn. Capillaria splenaecum) are nematodes that infect the liver and spleen, respectively, of mammals. While the host range, distribution, pathology and zoonotic potential of C. hepaticum are well known, very little is known about C. splenaecum. The observed prevalence of these two parasites, the factors associated with prevalence, and the lesions resulting in the different host species were studied in 408 micromammals captured in two periurban areas of Barcelona (NE Spain) from 2011 to 2013. C. hepaticum was found in 4 % of 322 wood mice (Apodemus sylvaticus) (with local prevalence up to 16 %) and 1 of 2 Norwegian rats (Rattus norvegicus). C. splenaecum was found in 10 % of 38 greater white-toothed shrew (Crocidura russula) (local prevalence up to 30 %). Neither parasite was detected in 29 Algerian mice (Mus spretus) and 17 black rats (Rattus rattus). Prevalence of C. hepaticum was significantly higher in wood mice captured in natural areas (6.4 %) than those from residential areas (0 %), and infected mice were in better body condition. No differences in prevalence were found among age and sex groups, years and seasons. Lesions of hepatic capillariasis in wood mice consisted mainly of mild to moderate multifocal granulomas around degenerating adult parasites and/or eggs, while lesions seen in a rat consisted of multifocal granulomatous hepatitis and bridging fibrosis extending from the necrotic areas caused by the parasites. Splenic lesions found in shrews due to C. splenaecum, representing the first histological description of this parasite, were single nodules that corresponded to finely encapsulated clusters of eggs with adult parasites.
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References
Chirife AD, Millán J (In press) Field immobilization of wood mouse (Apodemus sylvaticus) with medetomidine and ketamine and antagonism with atipamezole. J Wildl Dis
De Andrade SB, Andrade ZA (2004) Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice). Mem Inst Oswaldo Cruz 99:399–406
Farhang-Azad A (1977) Ecology of Capillaria hepatica (Bancroft 1893) (Nematoda). 1. Dynamics of infection among Norway rat populations of the Baltimore zoo, Baltimore, Maryland. J Parasitol 63:117–122
Freitas FJ, Lent H (1936) Estudo sobre Capillariinae parasitos de mamíferos (Nematoda: Trichuroidea). Mem Inst Oswaldo Cruz 31:84–175
Fuehrer HP (2014a) An overview of the host spectrum and distribution of Calodium hepaticum (syn. Capillaria hepatica): part 1—Muroidea. Parasitol Res 113:619–640
Fuehrer HP (2014b) An overview of the host spectrum and distribution of Calodium hepaticum (syn. Capillaria hepatica): part 2—Mammalia (excluding Muroidea). Parasitol Res 113:641–651
Fuehrer HP, Igel P, Auer H (2011) Capillaria hepatica in man—an overview of hepatic capillariosis and spurious infections. Parasitol Res 109:969–979
Gardiner CH, Poynton SL (1999) An atlas of metazoan parasites in animal tissues. American Registry of Pathology, Washington, 64 pp
Goüy de Bellocq J, Morand S, Feliú C (2002) Patterns of parasite species richness of western Palaearctic micro-mammals: island effects. Ecography 25:173–183
Klenzak J, Mattia A, Valenti A, Goldberg J (2005) Hepatic capillariasis in Maine presenting as a hepatic mass. Am J Trop Med Hyg 72:651–653
Meagher S (1998) Physiological responses of deer mice (Peromyscus maniculatus) to infection with Capillaria hepatica (Nematoda). J Parasitol 84:1112–1118
Peig J, Green AJ (2009) New perspectives for estimating body condition from mass⁄length data: the scaled mass index as an alternative method. Oikos 118:1883–1891
Portolés E, Granel P, Esteban JG, Cabaret J (2004) Helminth associations in white-toothed shrews Crocidura russula (Insectivora: Soricidae) from the Albufera Natural Park, Spain. J Parasitol 90:572–578
Reperant LA, Deplazes P (2005) Cluster of Capillaria hepatica infections in non-commensal rodents from the canton of Geneva, Switzerland. Parasitol Res 96:340–342
Resendes AR, Amaral AF, Rodrigues A, Almeria S (2009) Prevalence of Calodium hepaticum (Syn. Capillaria hepatica) in house mice (Mus musculus) in the Azores archipelago. Vet Parasitol 160:340–343
Spratt DM, Singleton GR (2001) Hepatic capillariasis. In: Samuel WM, Pybus MJ, Kocan AA (eds) Parasitic diseases of wild mammals. Iowa State University Press, Ames, pp 365–379
Acknowledgments
This study was funded by the project CGL2010-17931. JM held a “Ramón y Cajal” fellowship awarded by the Spanish MICINN and the European Social Fund. We wish to thank L. Cabañeros, F. Llimona and S. Cahill (Collserola Natural Park) and J. Torrent and A. Miño (St. Llorenç Natural Park) for facilitating our work in the field and L. Lobato, B. López and C. Linares for field assistance.
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Millán, J., Chirife, A.D., Proboste, T. et al. Factors associated with the prevalence and pathology of Calodium hepaticum and C. splenaecum in periurban micromammals. Parasitol Res 113, 3001–3006 (2014). https://doi.org/10.1007/s00436-014-3962-1
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DOI: https://doi.org/10.1007/s00436-014-3962-1