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Allograft inflammatory factor-1 alleviates liver disease of BALB/c mice infected with Schistosoma japonicum

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Abstract

Allograft inflammatory factor-1 (AIF-1) plays an important role in various inflammatory conditions. Our previous study demonstrated that AIF-1 was over-expressed in the liver of BALB/c mice infected with Schistosoma japonicum and played significant role in the pathogenesis of schistosomiasis. The aim of this study was to focus on the effect of AIF-1 treatment on liver fibrosis and necrosis of BALB/c mice infected with S. japonicum. Seventy-two BALB/c mice were infected with cercariae of S. japonicum and then divided into three groups: AIF-1-treated group, saline-treated group, and control group. The vital signs, liver function, egg load, and hepatic pathological changes of the mice were assessed, and the levels of AIF-1 and TNF-α in the liver and spleen were measured at 5, 8, and 14 weeks postinfection. The treatment of AIF-1 on the mice infected with S. japonicum suppressed the expression of TNF-α and increased the effectiveness of AIF-1 in the liver and spleen at 14 weeks postinfection. Histopathological analysis and Masson trichrome staining for the liver tissues showed that the liver fibrosis and necrosis were alleviated previously compared with other infected mice at 14 weeks postinfection. The treatment of AIF-1 on the mice infected with S. japonicum can alleviate hepatic fibrosis and necrosis which indicate that AIF-1 use may prevent and cure the liver fibrosis.

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References

  • Adewusi OI, Nix NA, Lu X, Colley DG, Secor WE (1996) Schistosoma mansoni: relationship of tumor necrosis factor-alpha to morbidity and collagen deposition in chronic experimental infection. Exp Parasito 84:115–123

    Article  CAS  Google Scholar 

  • Arnaud V, Li J, Wang Y, Fu X, Mengzhi S et al (2008) Regulatory role of interleukin-10 and interferon-gamma in severe hepatic central and peripheral fibrosis in humans infected with Schistosoma japonicum. J Infect Dis 198:418–426

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Autieri MV, Kelemen S, Thomas BA, Feller ED, Goldman BI et al (2002) Allograft inflammatory factor-1 expression correlates with cardiac rejection and development of cardiac allograft vasculopathy. Circulation 106:2218–2223

    Article  CAS  PubMed  Google Scholar 

  • Barker AK, McDaniel DO, Zhou X, He Z, Aru G et al (2010) Combined analysis of allograft inflammatory factor-1, interleukin-18, and Toll-like receptor expression and association with allograft rejection and coronary vasculopathy. Am Surg 76:872–878

    PubMed  Google Scholar 

  • Baron S (1996) Medical microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston. Available from: http://www.ncbi.nlm.nih.gov/books/NBK7627/; PMID: 21413252

  • Booth M, Mwatha JK, Joseph S, Jones FM, Kadzo H et al (2004) Periportal fibrosis in human Schistosoma mansoni infection is associated with low IL-10, low IFN-gamma, high TNF-alpha, or low RANTES, depending on age and gender. J Immunol 172:1295–1303

    Article  CAS  PubMed  Google Scholar 

  • Chen ZW, Ahren B, Ostenson CG, Cintra A, Bergman T et al (1997) Identification, isolation, and characterization of daintain (allograft inflammatory factor 1), a macrophage polypeptide with effects on insulin secretion and abundantly present in the pancreas of prediabetic BB rats. Proc Natl Acad Sci U S A 94:13879–13884

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Chen QR, Guan F, Yan DJ, Lei DS, Fu L et al (2012) The dynamic expression of allograft inflammatory factor-1 in hepatic tissues and splenic cells of BALB/c mice with Schistosoma japonicum infection. Tissue Antigens 79:33–41

    Article  CAS  PubMed  Google Scholar 

  • Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA (1999) An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 104:777–785

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Deininger MH, Meyermann R, Schluesener HJ (2002) The allograft inflammatory factor-1 family of proteins. FEBS Lett 514:115–121

    Article  CAS  PubMed  Google Scholar 

  • Del Galdo F, Artlett CM, Jimenez SA (2006) The role of allograft inflammatory factor 1 in systemic sclerosis. Curr Opin Rheumatol 18:588–593

    Article  PubMed  Google Scholar 

  • Gruen JR, Weissman SM (2001) Human MHC class III and IV genes and disease associations. Front Biosci 6:D960–D972

    Article  CAS  PubMed  Google Scholar 

  • Gryseels B, Polman K, Clerinx J, Kestens L (2006) Human schistosomiasis. Lancet 368:1106–1118

    Article  PubMed  Google Scholar 

  • Henri S, Chevillard C, Mergani A, Paris P, Gaudart J et al (2002) Cytokine regulation of periportal fibrosis in humans infected with Schistosoma mansoni: IFN-γ is associated with protection against fibrosis and TNF-α with aggravation of disease. J Immunol 169:929–936

    Article  CAS  PubMed  Google Scholar 

  • Kimura M, Kawahito Y, Obayashi H, Ohta M, Hara H et al (2007) A critical role for allograft inflammatory factor-1 in the pathogenesis of rheumatoid arthritis. J Immunol 178:3316–3322

    Article  CAS  PubMed  Google Scholar 

  • Li T, Feng Z, Jia S, Wang W, Du Z et al (2012) Daintain/AIF-1 promotes breast cancer cell migration by up-regulated TNF-α via activate p38 MAPK signaling pathway. Breast Cancer Res Treat 131:891–898

    Article  CAS  PubMed  Google Scholar 

  • Meurer SK, Tihaa L, Lahme B, Gressner AM, Weiskirchen R (2005) Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor β receptor signaling. J Biol Chem 280:3078–3087

    Article  CAS  PubMed  Google Scholar 

  • Mishima T, Iwabuchi K, Fujii S, Tanaka SY, Ogura H et al (2008) Allograft inflammatory factor-1 augments macrophage phagocytotic activity and accelerates the progression of atherosclerosis in ApoE-/- mice. Int J Mol Med 21:181–187

    CAS  PubMed  Google Scholar 

  • Morohashi T, Iwabuchi K, Watano K, Dashtsoodol N, Mishima T et al (2003) Allograft inflammatory factor-1 regulates trinitrobenzene sulphonic acid-induced colitis. Immunology 110:112–119

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Mwatha JK, Kimani G, Kamau T, Mbugua GG, Ouma JH et al (1998) High levels of TNF, soluble TNF receptors, soluble ICAM-1, and IFN-γ, but low levels of IL-5, are associated with hepatosplenic disease in human schistosomiasis mansoni. J Immunol 160:1992–1999

    CAS  PubMed  Google Scholar 

  • Neville MJ, Campbell RD (1999) A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. J Immunol 162:4745–4754

    CAS  PubMed  Google Scholar 

  • Silva-Teixeira DN, Contigli C, Lambertucci JR, Serufo JC, Rodrigues V Jr (2004) Gender-related cytokine patterns in sera of schistosomiasis patients with Symmers’ fibrosis. Clin Diagn Lab Immunol 11:627–630

    CAS  PubMed Central  PubMed  Google Scholar 

  • Talaat RM, El-Bassiouny AI, Osman AM, Yossif M, Charmy R et al (2007) Cytokine secretion profile associated with periportal fibrosis in S. mansoni-infected Egyptian patients. Parasitol Res 101:289–299

    Article  PubMed  Google Scholar 

  • Tian Y, Kelemen SE, Autieri MV (2006) Inhibition of AIF-1 expression by constitutive siRNA expression reduces macrophage migration, proliferation, and signal transduction initiated by atherogenic stimuli. Am J Physiol Cell Physiol 290:C1083–1091

    Article  CAS  PubMed  Google Scholar 

  • Utans U, Arceci RJ, Yamashita Y, Russell ME (1995) Cloning and characterization of allograft inflammatory factor-1: a novel macrophage factor identified in rat cardiac allografts with chronic rejection. J Clin Invest 95:2954–2962

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Utans U, Quist WC, McManus BM, Wilson JE, Arceci RJ (1996) Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts. Transplantation 61:1387–1392

    Article  CAS  PubMed  Google Scholar 

  • Wang CZ, Mo HM, Cheng YL, Wang L, Jiang ZW et al (2007) Production and identification of chicken egg yolk antibodies against soluble egg antigen of Schistosoma japonicum. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 25:193–197

    PubMed  Google Scholar 

  • Wang W, Huang B, Feng ZG, Chen XP, Tang WX et al (2010) Expression, purification, and characterization of functional recombinant human daintain/AIF-1 in Escherichia coli. Z Naturforsch C 65:726–732

    PubMed  Google Scholar 

  • Wu JM, Thoburn CJ, Wisell J, Farmer ER, Hess AD (2010) CD20, AIF-1, and TGF-beta in graft-versus-host disease: a study of mRNA expression in histologically matched skin biopsies. Mod Pathol 23:720–728

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Wynn TA (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214:199–210

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Wynn TA, Barron L (2010) Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis 30:245–257

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Yang ZF, Ho DW, Lau CK, Lam CT, Lum CT et al (2005) Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages. Int Immunol 17:1391–1397

    Article  CAS  PubMed  Google Scholar 

  • Yang ZF, Ho DW, Ngai P, Lau CK, Zhao Y et al (2007) Anti-inflammatory properties of IL-10 rescue small-for-size liver grafts. Liver Transpl 13:558–565

    Article  PubMed  Google Scholar 

  • Yu L, Sun X, Yang F, Yang J, Shen J et al (2012) Inflammatory cytokines IFN-γ, IL-4, IL-13 and TNF-α alterations in schistosomiasis: a meta-analysis. Parasitol Res 110:1547–1552

    Article  PubMed  Google Scholar 

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Acknowledgement

This work was supported by the National Natural Science Foundation of China (81201310) and the Fundamental Research Funds for the Central Universities, HUST (2012QN138).

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Authors and Affiliations

  1. Department of Pathology, Hubei Cancer Hospital, Wuhan, China

    Qiong-Rong Chen & Chun-Mei Chen

  2. Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China

    Fei Guan, Jia-Hui Lei & An-Ou Niu

  3. Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

    Qiong-Rong Chen, Shu-Mei Song & Jian-Kang Jin

  4. Medicine Laboratory, Hubei Cancer Hospital, Wuhan, China

    Dan-Sheng Lei

  5. Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China

    Zheng-Wang Chen

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  1. Qiong-Rong Chen
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  2. Fei Guan
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Correspondence to Fei Guan.

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Chen, QR., Guan, F., Song, SM. et al. Allograft inflammatory factor-1 alleviates liver disease of BALB/c mice infected with Schistosoma japonicum . Parasitol Res 113, 2629–2639 (2014). https://doi.org/10.1007/s00436-014-3915-8

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  • DOI: https://doi.org/10.1007/s00436-014-3915-8

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