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Susceptibility or resistance of praziquantel in human schistosomiasis: a review

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Abstract

Since praziquantel was developed in 1970s, it has replaced other antischistosomal drugs to become the only drug of choice for treatment of human schistosomiases, due to high efficacy, excellent tolerability, few and transient side effects, simple administration, and competitive cost. Praziquantel-based chemotherapy has been involved in the global control strategy of the disease and led to the control strategy shifting from disease control to morbidity control, which has greatly reduced the prevalence and intensity of infections. Given that the drug has been widely used for morbidity control in endemic areas for more than three decades, the emergence of resistance of Schistosoma to praziquantel under drug selection pressure has been paid much attention. It is possible to induce resistance of Schistosoma mansoni and Schistosoma japonicum to praziquantel in mice under laboratorial conditions, and a reduced susceptibility to praziquantel in the field isolates of S. mansoni has been found in many foci. In addition, there are several schistosomiasis cases caused by Schistosoma haematobium infections in which repeated standard treatment fails to clear the infection. However, in the absence of exact mechanisms of action of praziquantel, the mechanisms of drug resistance in schistosomes remain unclear. The present review mainly demonstrates the evidence of drug resistance in the laboratory and field and the mechanism of praziquantel resistance and proposes some strategies for control of praziquantel resistance in schistosomes.

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Acknowledgments

This study was supported by grants from the National Science and Technology Pillar Program of China (2009BAI78B06), Jiangsu Department of Health (X200901, X200912, and X201111), Jiangsu Provincial Scientific Foundation of Preventive Medicine (Y201031), and Jiangsu Provincial Scholarship.

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  1. Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, Wuxi City, Jiangsu Province, 214064, People’s Republic of China

    Wei Wang & You-Sheng Liang

  2. Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, Wuxi City, Jiangsu Province, 214064, People’s Republic of China

    Wei Wang & You-Sheng Liang

  3. Wuxi Institute for Drug Control, 111 Xinmin Road, Wuxi City, Jiangsu Province, 214021, People’s Republic of China

    Li Wang

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Wang, W., Wang, L. & Liang, YS. Susceptibility or resistance of praziquantel in human schistosomiasis: a review. Parasitol Res 111, 1871–1877 (2012). https://doi.org/10.1007/s00436-012-3151-z

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