Advertisement

Parasitology Research

, Volume 111, Issue 5, pp 1895–1899 | Cite as

Essential oil components from Asarum sieboldii Miquel are toxic to the house dust mite Dermatophagoides farinae

  • Haiqiang WuEmail author
  • Jing Li
  • Fang Zhang
  • Li Li
  • Zhigang Liu
  • Zhendan He
Original Paper

Abstract

In our effort to develop novel plant-derived acaricides, we examined the contact and fumigant toxicity of Asarum heterotropoides (Asarum sieboldii Miquel) essential oil constituents to the house dust mite Dermatophagoides farinae (Acari: Pyroglyphidae). Ten constituents, including methyl eugenol (relative amount 42.18 %), were identified by gas chromatography-mass spectroscopy (GC-MS) in the A. sieboldii Miq. essential oil. In contact toxicity tests, methyl eugenol (4.2 μg/cm2, 24 h LD50) was most toxic to D. farinae, followed by benzyl benzoate (9.1 μg/cm2), A. sieboldii Miq. essential oil (37.7 μg/cm2), and dibutyl phthalate (DBP 57.9 μg/cm2). The potency of methyl eugenol and A. sieboldii Miq. essential oil was higher than benzyl benzoate and DBP, with mortalities of 100, 100, 94.6, and 13.2 %, respectively, after 2.5 h of exposure. In the vapor phase mortality bioassay, methyl eugenol and A. sieboldii Miq. essential oil resulted in 100 % mortality in closed containers after 24-h exposure, but only 4.7 and 7.9 %, respectively, in open containers, indicating that the toxicity in these tests was largely due to the vapor phase. Methyl eugenol and A. sieboldii Miq. essential oil merit further study as potential D. farinae control compounds.

Keywords

House Dust Mite Methyl Eugenol Acaricidal Activity Contact Toxicity Benzyl Benzoate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This study was supported by a grant from the Planned Science and Technology Project of Shenzhen (JSA200903190973A).

References

  1. Abbott WSA (1987) Method of computing the effectiveness of an insecticide. J Am Mosq Control Assoc 3(2):302–303PubMedGoogle Scholar
  2. Bush RK (2008) Indoor allergens, environmental avoidance, and allergic respiratory disease. Allergy Asthma Proc 29(6):575–579PubMedCrossRefGoogle Scholar
  3. Collins DA (2006) A review of alternatives to organophosphorus compounds for the control of storage mites. J Stored Prod Res 42(4):395–426CrossRefGoogle Scholar
  4. Dekeyser MA (2005) Acaricide mode of action. Pest Manag Sci 61(2):103–110PubMedCrossRefGoogle Scholar
  5. Fain A, Guerin B, Hart BG (1990) Mite and allergic disease. Allerbio, Varennes en Argonne, France, p 190Google Scholar
  6. Gaffin JM, Phipatanakul W (2009) The role of indoor allergens in the development of asthma. Curr Opin Allergy Clin Immunol 9(2):128–135PubMedCrossRefGoogle Scholar
  7. Jacquet A (2011) The role of innate immunity activation in house dust mite allergy. Trends Mol Med 17(10):604–611PubMedCrossRefGoogle Scholar
  8. Jeong EY, Kim MG, Lee HS (2009) Acaricidal activity of triketone analogues derived from Leptospermum scoparium oil against house-dust and stored-food mites. Pest Manag Sci 65(3):327–331PubMedCrossRefGoogle Scholar
  9. Kim EH, Kim HK, Ahn YJ (2003) Acaricidal activity of clove bud oil compounds against Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). J Agric Food Chem 51(4):885–889PubMedCrossRefGoogle Scholar
  10. Kim HK, Kim JR, Ahn YJ (2004) Acaricidal activity of cinnamaldehyde and its congeners against Tyrophagus putrescentiae (Acari: Acaridae). J Stored Prod Res 40(1):55–63CrossRefGoogle Scholar
  11. Kim SI, Na YE, Yi JH, Kim BS, Ahn YJ (2007) Contact and fumigant toxicity of oriental medicinal plant extracts against Dermanyssus gallinae (Acari: Dermanyssidae). Vet Parasitol 145(3–4):377–382PubMedCrossRefGoogle Scholar
  12. Kim HK, Yun YK, Ahn YJ (2008) Fumigant toxicity of cassia bark and cassia and cinnamon oil compounds to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). Exp Appl Acarol 44(1):1–9PubMedCrossRefGoogle Scholar
  13. Kwon JH, Ahn YJ (2002) Acaricidal activity of butylidenephthalide identified in Cnidium officinale rhizome against Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). J Agric Food Chem 50(16):4479–4483PubMedCrossRefGoogle Scholar
  14. Lee HS (2004) Acaricidal activity of constituents identified in Foeniculum vulgare fruit oil against Dermatophagoides spp. (Acari: Pyroglyphidae). J Agric Food Chem 52(10):2887–2889PubMedCrossRefGoogle Scholar
  15. Lee CH, Park JM, Song HY, Jeong EY, Lee HS (2009) Acaricidal activities of major constituents of essential oil of Juniperus chinensis leaves against house dust and stored food mites. J Food Prot 72(8):1686–1691PubMedGoogle Scholar
  16. Leung TF, Ko FW, Wong GW (2012) Roles of pollution in the prevalence and exacerbations of allergic diseases in Asia. J Allergy Clin Immunol 129(1):42–47PubMedCrossRefGoogle Scholar
  17. Locher N, Al-Rasheid KA, Abdel-Ghaffar F, Mehlhorn H (2010) In vitro and field studies on the contact and fumigant toxicity of a neem-product (Mite-Stop) against the developmental stages of the poultry red mite Dermanyssus gallinae. Parasitol Res 107(2):417–423PubMedCrossRefGoogle Scholar
  18. Maas T, Kaper J, Sheikh A, Knottnerus JA, Wesseling G, Dompeling E, Muris JW, van Schayck CP (2009) Mono and multifaceted inhalant and/or food allergen reduction interventions for preventing asthma in children at high risk of developing asthma. Cochrane Database Syst Rev 8(3):CD006480Google Scholar
  19. Mehlhorn H, Walldorf V, Abdel-Ghaffar F, Al-Quraishy S, Al-Rasheid KA, Mehlhorn J (2012) Biting and bloodsucking lice of dogs-treatment by means of a neem seed extract (MiteStop, Wash Away Dog). Parasitol Res 110(2):769–773PubMedCrossRefGoogle Scholar
  20. Pollart SM, Ward GW Jr, Platts-Mills TAE (1987) House dust sensitivity and environmental control. Immunol Allergy Clin N Am 7:447–461Google Scholar
  21. Rim IS, Jee CH (2006) Acaricidal effects of herb essential oils against Dermatophagoides farinae and D. pteronyssinus (Acari: Pyroglyphidae) and qualitative analysis of a herb Mentha pulegium (pennyroyal). Korean J Parasitol 44(2):133–138PubMedCrossRefGoogle Scholar
  22. SAS Institute (2004) SAS OnlineDoc, Version 8.01. Statistical analysis system institute, CaryGoogle Scholar
  23. Schmahl G, Al-Rasheid KA, Abdel-Ghaffar F, Klimpel S, Mehlhorn H (2010) The efficacy of neem seed extracts (Tre-san, MiteStop) on a broad spectrum of pests and parasites. Parasitol Res 107(2):261–269PubMedCrossRefGoogle Scholar
  24. Semic Jusufagic A, Simpson A, Woodcock A (2006) Dust mite allergen avoidance as a preventive and therapeutic strategy. Curr Allergy Asthma Rep 6(6):521–526PubMedCrossRefGoogle Scholar
  25. Williamson EM, Priestley CM, Burgess IF (2007) An investigation and comparison of the bioactivity of selected essential oils on human lice and house dust mites. Fitoterapia 78(7–8):521–525PubMedCrossRefGoogle Scholar
  26. Wu HQ, Li L, Li J, He ZD, Liu ZG, Zeng QQ, Wang YS (2012) Acaricidal activity of DHEMH, derived from patchouli oil, against house dust mite, Dermatophagoides farinae. Chem Pharm Bull(Tokyo) 60(2):178–182CrossRefGoogle Scholar
  27. Xie W, Lu M (1995) Asarum essential oil with the pharmacological effects. Ningxia Med J 12(2):121–124Google Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Haiqiang Wu
    • 1
    Email author
  • Jing Li
    • 2
  • Fang Zhang
    • 1
  • Li Li
    • 1
  • Zhigang Liu
    • 2
  • Zhendan He
    • 2
  1. 1.College of Life SciencesShenzhen UniversityShenzhenChina
  2. 2.Institute of Allergy and Immunology, College of MedicineShenzhen UniversityShenzhenChina

Personalised recommendations