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Efficacy of trans-cinnamaldehyde against Psoroptes cuniculi in vitro

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Abstract

The acaricidal activity of trans-cinnamaldehyde was evaluated in vitro on Psoroptes cuniculi. In this study, different concentrations of trans-cinnamaldehyde were tested, and the observed mites mortality was compared with that observed in untreated and treated (Acacerulen R®) controls. The morphological changes in P. cuniculi treated with trans-cinnamaldehyde were examined with light microscopy. By the analysis of variance one-way test, up to 8 μg/ml of trans-cinnamaldehyde gave highly significant (P < 0.01) percentages of mite mortality compared with the untreated controls, but only up to 256 μg/ml, it showed the same efficacy of Acacerulen R®. At the same time, a bioassay was conducted by exposing mites to varying doses of trans-cinnamaldehyde in vitro cultures. The resulting data were analyzed by using a time–dose–mortality modeling technique, yielding the parameters for time and dose effects of P. cuniculi. The β value was 2.01, indicating that trans-cinnamaldehyde had a good activity to kill P. cuniculi adults. Based on the time–dose–mortality relationships fitted and the virulence indices estimated, trans-cinnamaldehyde is a promising microbial agent for mites control.

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Acknowledgments

Financial supports for this work came from the National Key Technology R&D Program (2008BADB4B05), the National Nature Science Foundation of China (No. 30871889), the Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) (No. 200801831051), the Fund for Science and the earmarked fund for China Agriculture Research System (cars-38), and the Fundamental Research Funds for the Central Universities.

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Authors and Affiliations

  1. Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, 130062, People’s Republic of China

    Fengge Shen, Mingxun Xing, Lihui Liu, Wei Wang, Xiuping Wu, Xuelin Wang, Xinrui Wang, Guangming Wang, Junhui Zhang, Lei Li & Lu Yu

  2. Key Laboratory of Veterinary Drug Discovery, Ministry of Agriculture, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics, Chinese Academy of Agricultural Sciences, Lanzhou, 730050, People’s Republic of China

    Jiyu Zhang

  3. State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese Center for Disease Control and Prevention, Beijing, 100176, People’s Republic of China

    Lu Yu

  4. Key Lab for New Drug Research of TCM, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, People’s Republic of China

    Xudong Tang

  5. College of Veterinary Medicine, Northwest A&F University, Shanxi Yangling, 712100, People’s Republic of China

    Xiaohong Wang

Authors
  1. Fengge Shen
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  2. Mingxun Xing
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  3. Lihui Liu
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  5. Wei Wang
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  6. Xiaohong Wang
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  7. Xiuping Wu
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  8. Xuelin Wang
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  9. Xinrui Wang
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  10. Guangming Wang
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  11. Junhui Zhang
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  12. Lei Li
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  13. Jiyu Zhang
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  14. Lu Yu
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Corresponding authors

Correspondence to Jiyu Zhang or Lu Yu.

Additional information

Fengge Shen, Mingxun Xing, Lihui Liu, Xudong Tang, Wei Wang, Xiaohong Wang, Xiuping Wu, Xuelin Wang, Xinrui Wang, Guangming Wang, Junhui Zhang, and Lei Li contributed equally to this study.

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Shen, F., Xing, M., Liu, L. et al. Efficacy of trans-cinnamaldehyde against Psoroptes cuniculi in vitro. Parasitol Res 110, 1321–1326 (2012). https://doi.org/10.1007/s00436-012-2816-y

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  • DOI: https://doi.org/10.1007/s00436-012-2816-y

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