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The effect of self-licking behavior on pharmacokinetics of eprinomectin and clinical efficacy against Psoroptes cuniculi in topically administered rabbits

Parasitology Research volume 106, pages 607–613 (2010)Cite this article

Abstract

Ear mange mite Psoroptes cuniculi, one of the predominant parasites in rabbits, can cause considerable weight loss, low favorable fee conversion rates, and meningitis. The present experiment was to investigate the difference of plasma disposition and the variation of clinical efficacy under the effect of animal self-licking behavior in topically administered rabbits. Ten rabbits for pharmacokinetic study in two groups (the self-licking and the non-licking) were topically administered with 1 mg kg−1 of eprinomectin. In the self-licking group, rabbits were allowed to self-lick freely, while, to prevent self-licking, each animal in the non-licking group was fitted with a pet collar. Compared to the non-licking group, self-licking behavior contributed to an extremely significant shorter half-life of absorption (14.85 ± 2.79 h in licking group vs. 29.44 ± 7.81 h in non-licking group, p < 0.01) and an extremely significant higher C max value for eprinomectin (21.95 ± 5.36 h in licking group vs. 6.98 ± 0.72 ng ml−1 in non-licking group, p < 0.01) in plasma disposition. An extremely significantly shorter mean residence time (50.72 ± 3.45 h) in self-licking group was also determined compared with the value obtained in non-licking group (106.66 ± 7.39 h; p < 0.01). Clinical efficacy study of eprinomectin was examined in rabbits naturally infested with P. cuniculi which were randomly allocated in three groups: the self-licking, the non-licking, and control groups. All rabbits in the self-licking and the non-licking groups were treated with topical eprinomectin at a single dose of 2 mg kg−1 (day 0). Topical eprinomection led to a complete parasitological recovery in both treated groups on day 14 and remained free of live mites and clinical lesions from day 21 to the end of the study period (day 35).

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References

  • Alvinerie M, Sutra JF, Galtier P, Mage C (1999) Pharmacokinetics of eprinomectin in plasma and milk following topical administration to lactating dairy cattle. Res Vet Sci 67:229–232

    Article  CAS  PubMed  Google Scholar 

  • Baker DG (1998) Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin Microbiol Rev 11:231–266

    CAS  PubMed  Google Scholar 

  • Baoliang P, Yuwan W, Zhende P, Lifschitz AL, Ming W (2006) Pharmacokinetics of eprinomectin in plasma and milk following subcutaneous administration to Lactating dairy cattle. Vet Res Commun 30:263–270

    Article  CAS  PubMed  Google Scholar 

  • Bousquet-Melou A, Mercadier S, Alvinerie M, Toutain PL (2004) Endectocide exchanges between grazing cattle after pour-on administration of doramectin, ivermectin and moxidectin. Int J Parasitol 34:1299–1307

    Article  CAS  PubMed  Google Scholar 

  • Bowman DD, Fogelson ML, Carbone LG (1992) Effect of ivermectin on the control of ear mites (Psoroptes cuniculi) in naturally infested rabbits. Am J Vet Res 53:105–109

    CAS  PubMed  Google Scholar 

  • Curtis SK, Housley R, Brooks DL (1990) Use of ivermectin for treatment of ear mite infestation in rabbits. J Am Vet Med Assoc 196:1139–1140

    CAS  PubMed  Google Scholar 

  • Dupuy J, Sutra JF, Alvinerie M, Rinaldi L, Veneziano V, Mezzino L, Pennacchio S, Cringoli G (2008) Plasma and milk kinetic of eprinomectin and moxidectin in lactating water buffaloes (Bubalus bubalis). Vet Parasitol 157:284–290

    Article  CAS  PubMed  Google Scholar 

  • Farmaki R, Koutinas AF, Papazahariadou MG, Kasabalis D, Day MJ (2009) Effectiveness of a selamectin spot-on formulation in rabbits with sarcoptic mange. Vet Rec 164:431–432

    CAS  PubMed  Google Scholar 

  • Hansen O, Gall Y, Pfister K, Beck W (2005) Efficacy of a formulation containing imidacloprid and moxidectin against naturally acquired ear mite infestations (Psoroptes cuniculi) in rabbits. Intern J Appl Res Vet Med 3:281–286

    CAS  Google Scholar 

  • Kakuma Y, Takeuchi Y, Mori Y, Hart BL (2003) Hormonal control of grooming behavior in domestic goats. Physiol Behav 78:61–66

    Article  CAS  PubMed  Google Scholar 

  • Kanbur M, Atalay O, Ica A, Eraslan G, Cam Y (2008) The curative and antioxidative efficiency of doramectin and doramectin+vitamin AD3E treatment on Psoroptes cuniculi infestation in rabbits. Res Vet Sci 85:291–293

    Article  CAS  PubMed  Google Scholar 

  • Kurade NP, Bhat TK, Jithendran KP (1996) Effect of ivermectin against ear mange mite (Psoroptes cuniculi) in naturally infested rabbits. World Rabbit Sci 4:25–27

    Google Scholar 

  • Kurtdede A, Karaer Z, Acar A, Guzel M, Cingi CC, Ural K, Ica A (2007) Use of selamectin for the treatment of psoroptic and sarcoptic mite infestation in rabbits. Vet Dermatol 18:18–22

    Article  PubMed  Google Scholar 

  • Laffont CM, Alvinerie M, Bousquet-Melou A, Toutain PL (2001) Licking behaviour and environmental contamination arising from pour-on ivermectin for cattle. Int J Parasitol 31:1687–1692

    Article  CAS  PubMed  Google Scholar 

  • Laffont CM, Bousquet-Melou A, Bralet D, Alvinerie M, Fink-Gremmels J, Toutain PL (2003) A pharmacokinetic model to document the actual disposition of topical ivermectin in cattle. Vet Res 34:445–460

    Article  CAS  PubMed  Google Scholar 

  • McTier TL, Hair JA, Walstrom DJ, Thompson L (2003) Efficacy and safety of topical administration of selamectin for treatment of ear mite infestation in rabbits. J Am Vet Med Assoc 223:322–324

    Article  CAS  PubMed  Google Scholar 

  • Perrier D, Gibaldi M (1982) General derivation of the equation for time to reach a certain fraction of steady state. J Pharm Sci 71:474–475

    Article  CAS  PubMed  Google Scholar 

  • Prosl H, Kanout AG (1985) Treatment of ear mange in rabbits with ivermectin. Berl Münch tierärztl Wochenschr 98:45–47

    CAS  PubMed  Google Scholar 

  • Rowland M, Tozer TN (1995) Clinical pharmacokinetics: concepts and application. Williams and Wilkins, Baltimore, p 60

    Google Scholar 

  • Sallovitz JM, Lifschitz A, Imperiale F, Virkel G, Larghi J, Lanusse C (2005) Doramectin concentration profiles in the gastrointestinal tract of topically-treated calves: influence of animal licking restriction. Vet Parasitol 133:61–70

    Article  CAS  PubMed  Google Scholar 

  • Sato S, Tarumizu K, Hatae K (1993) The influence of social factors on allogrooming in cows. Appl Anim Behav Sci 38:235–244

    Article  Google Scholar 

  • Simonsen HB (1979) Grooming behaviour of domestic cattle. Nord Vet Med 31:1–5

    CAS  PubMed  Google Scholar 

  • Ulutas B, Voyvoda H, Bayramli G, Karagenc T (2005) Efficacy of topical administration of eprinomectin for treatment of ear mite infestation in six rabbits. Vet Dermatol 16:334–337

    Article  PubMed  Google Scholar 

  • Wagner R, Wendlberger U (2000) Field efficacy of moxidectin in dogs and rabbits naturally infested with Sarcoptes spp., Demodex spp. and Psoroptes spp. mites. Vet Parasitol 93:149–158

    Article  CAS  PubMed  Google Scholar 

  • Wright FC, Riner JC (1985) Comparative efficacy of injection routes and doses of ivermectin against Psoroptes in rabbits. Am J Vet Res 46:752–754

    CAS  PubMed  Google Scholar 

  • Yamada Y, Haraguchi N, Uchida K, Meng Y (1993) Jaw movements and EMG activities of limb-licking behavior during grooming in rabbits. Physiol Behav 53:301–307

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgment

We gratefully acknowledge the funding of this work by the Scientific and Technological Ministry (2006BAD31B07 and 2006BAD04A05-03), and the Agricultural Ministry (National Dairy Industry Research System), China.

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Authors and Affiliations

  1. College of Veterinary Medicine, Key Laboratory of Development and Evaluation of the Chemical and Herbal Drugs for Animal Use, China Agricultural University, 100193, Beijing, China

    Huiqiang Wen, Baoliang Pan, Fangfei Wang, Zhenzhong Yang, Zhujun Wang, Shuai Liu & Ming Wang

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  1. Huiqiang Wen
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  2. Baoliang Pan
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  3. Fangfei Wang
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  4. Zhenzhong Yang
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  5. Zhujun Wang
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  6. Shuai Liu
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  7. Ming Wang
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Correspondence to Ming Wang.

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Huiqiang Wen and Baoliang Pan shared as first authors.

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Wen, H., Pan, B., Wang, F. et al. The effect of self-licking behavior on pharmacokinetics of eprinomectin and clinical efficacy against Psoroptes cuniculi in topically administered rabbits. Parasitol Res 106, 607–613 (2010). https://doi.org/10.1007/s00436-009-1704-6

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  • DOI: https://doi.org/10.1007/s00436-009-1704-6

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