Parasitology Research

, Volume 105, Issue 4, pp 893–898 | Cite as

Toxoplasma gondii: host–parasite interaction and behavior manipulation

  • Rodrigo Costa da SilvaEmail author
  • Helio Langoni


Toxoplasma gondii is an obligate intracellular parasite that causes different lesions in men and other warm-blooded animals. Humoral and cellular immune response of the host against the parasite keeps the protozoan in a latent stage, and clinical disease ensues when immunological response is compromised. Brain parasitism benefits the parasite causing behavioral changes in the host, not only in animals but also in humans. Schizophrenia and epilepsy are two neurological disorders that have recently been reported to affect humans coinfected with T. gondii. Further studies based on host–parasite interaction in several wild or domestic warm-blooded species are still necessary in order to better understand parasitism and behavioral changes caused by T. gondii.


Schizophrenia Natural Killer Cell Microglial Cell Toxoplasmosis Parasitophorous Vacuole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank UNESP for the logistical support and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) for the Ph.D. grant # 2006/02486-4 and financial support # 2006/07198-7.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Veterinary Hygiene and Animal Science (DHVSP), College of Veterinary Medicine and Animal Science (FMVZ)São Paulo State University (UNESP)BotucatuBrazil

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