Parasitology Research

, Volume 104, Issue 6, pp 1321–1326 | Cite as

Signal sequence analysis of protein sequences from the filarial nematode parasite Brugia malayi and the evolution of secreted proteins in parasites

  • Xijuan Ying
  • Xiaobin Chen
  • Yinan Wang
  • Wenzhen Fang
  • Damin Luo
Original Paper


Taking a genomic approach to characterize potential secreted products, we analyzed putative protein sequences from Brugia malayi whole-genome shotgun sequencing project. SignalP analysis was applied to predict protein sequences and to identify potential signal peptides and anchors. We randomly analyzed 552 sequences, of which 88 (15.9%) bear predicted signal sequence coding regions. Through comparisons of sequences with homologs from other species, we found that although some of the sequences with signal sequences have no homologs with others, there are almost the same amounts of the sequences with signals which are highly conserved. Considering the distribution of secretory proteins of B. malayi in three categories has not made big differences, and most of the homologues of free-living nematodes of these secretory proteins also contained either N-signal signal peptides or signal anchors; we speculated that secretory proteins may be in the same evolutional status as the non-secretory proteins.

Supplementary material

436_2009_1331_MOESM1_ESM.doc (596 kb)
ESM Table 1Blast results of protein sequences of Brugia malayi (DOC 596 KB)


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Xijuan Ying
    • 1
  • Xiaobin Chen
    • 2
  • Yinan Wang
    • 1
  • Wenzhen Fang
    • 1
  • Damin Luo
    • 3
  1. 1.Biology Department, School of Life SciencesXiamen UniversityXiamenChina
  2. 2.College of Agriculture and BiologyShanghai Jiao Tong UniversityShanghaiChina
  3. 3.Key Laboratory for Subtropical Wetland Ecosystem ResearchXiamen University, Ministry of Education, CHINAXiamenChina

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