Abstract
The petroleum ether extract of Viola websteri Hemsl. (Violaceae) was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. The main antiplasmodial principles, 6-(8′Z-pentadecenyl)-salicylic acid (1) and 6-(8′Z, 11′Z, 14′Z-heptadecatrienyl)-salicylic acid (2), have been isolated from V. websteri for the first time. This is the first report on the antiplasmodial activity of the compounds from V. websteri.
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Acknowledgment
This work was supported by the MRC program of MOST/KOSEF (grant #: R13-2005-013-01000-0), Korea.
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Won-Hwan Park and Hyung-In Moon equally contributed to this work.
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Lee, S.J., Park, WH. & Moon, HI. Bioassay-guided isolation of antiplasmodial anacardic acids derivatives from the whole plants of Viola websteri Hemsl. Parasitol Res 104, 463–466 (2009). https://doi.org/10.1007/s00436-008-1205-z
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DOI: https://doi.org/10.1007/s00436-008-1205-z