Abstract
In opposite to the free-living soil nematode Caenorhabditis elegans, the genetic regulation of hypobiosis or inhibited or arrested development in parasitic nematodes is completely unknown. In C. elegans, the daf-genes or the age-1 gene are of major importance in signaling pathways regulating arrested development. To investigate if orthologs of these genes are present in the bovine lungworm Dictyocaulus viviparus, a PCR analysis with gene-specific primer combinations was performed. No orthologs of the age-1 or daf-genes could be identified in D. viviparus. The possible differences in the role of the daf-genes concerning arrested development in parasitic and free-living nematodes will be discussed.
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Acknowledgment
Funding support by a grant of the Karl-Enigk-Stiftung to Christina Strube is gratefully acknowledged. The nucleotide data reported in this paper have been submitted to the GenBank database under accession numbers EI367052–EI367121.
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Strube, C., von Samson-Himmelstjerna, G. & Schnieder, T. Genetic regulation of arrested development in nematodes: are age-1 and daf-gene orthologs present in Dictyocaulus viviparus?. Parasitol Res 101, 1111–1115 (2007). https://doi.org/10.1007/s00436-007-0594-8
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DOI: https://doi.org/10.1007/s00436-007-0594-8