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Parasitology Research

, Volume 101, Issue 2, pp 343–349 | Cite as

Effects of acute Plasmodium falciparum malaria on body weight in children in an endemic area

  • Akintunde SowunmiEmail author
  • Grace O. Gbotosho
  • Ahmed A. Adedeji
  • Babasola A. Fateye
  • Morenikeji F. Sabitu
  • Christian T. Happi
  • Fatai A. Fehintola
Original Paper

Abstract

The impacts of acute falciparum malaria on body weight and the host and parasite factors predictive of change in body weight were characterized in 465 prospectively studied children in an endemic area of southwest Nigeria. Pre-treatment weights were significantly lower than the 14 to 28-day post-treatment weights (P = 0.0001). In 187 children, fractional fall in body weight (FFBW) exceeded 4.9%. FFBW correlated negatively with age and body weight (P = 0.014 and 0.0001, respectively), but not with enrolment parasitaemia. In a multiple regression model, an age ≤5 years (AOR = 2.03, 95% CI 1.2–3.2, P = 0.003), a hematocrit ≤29% (AOR = 1.6, 95% CI 1.0–2.3, P = 0.037), and a body weight ≤9.6 kg (AOR = 5.4, 95% CI 1.7–20, P = 0.003) were independent predictors of FFBW ≥5% at presentation. Children who, after initial clearance, had recurrence of their parasitaemia within 28 days had a significantly higher propensity not to gain weight than children who were aparasitaemic after treatment (log-rank statistic 6.76, df = 1, P = 0.009). These results indicate that acute malaria contribute to sub-optimal growth in young children and may have implications for malaria control efforts in sub-Saharan Africa.

Keywords

Malaria Falciparum Malaria Artesunate Plasmodium Falciparum Malaria Amodiaquine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The study received financial support from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases. AS was supported by a WHO/TDR Career Development Award. We thank our clinic nurse and assistant, Moji Amao and Adeola Alabi, respectively, for help with running the study.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Akintunde Sowunmi
    • 1
    • 2
    Email author
  • Grace O. Gbotosho
    • 1
  • Ahmed A. Adedeji
    • 1
  • Babasola A. Fateye
    • 1
  • Morenikeji F. Sabitu
    • 1
  • Christian T. Happi
    • 1
  • Fatai A. Fehintola
    • 1
  1. 1.Department of Pharmacology & Therapeutics and Institute for Medical Research and TrainingUniversity of IbadanIbadanNigeria
  2. 2.Department of Clinical PharmacologyUniversity College HospitalIbadanNigeria

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