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Albendazole therapy for eosinophilic meningitis caused by Angiostrongylus cantonensis

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Abstract

Eosinophilic meningitis in humans is commonly caused by the nematode Angiostrongylus cantonensis. A severe headache is the most common presenting symptom. A prospective, randomized, double-blind, placebo, controlled study was conducted to determine if albendazole was efficacious in relieving such headaches. Seventy-one patients (36 and 35 in the treatment and control groups) were enrolled in the study. Five patients (two and three in the treatment and control groups) were excluded from the study because of being lost to follow-up, and the clinical data were incomplete. Therefore, 34 and 32 patients in the treatment and control groups were studied, respectively. Albendazole was administered at 15 mg/kg/day or identical placebo for 2 weeks. The number of patients with persistent headaches after 2 weeks was 7 and 13 in the albendazole and placebo groups (p = 0.08), respectively. The mean duration of a headache was 8.9 and 16.2 days in the albendazole and placebo groups, respectively (p = 0.05). No serious drug events were observed. A 2-week course of albendazole appeared to reduce the duration of headache in eosinophilic meningitis.

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References

  • Boongird P, Phuapradit P, Siridej N, Chirachariyavej T, Chuahirun S, Vejjajiva A (1977) Neurological manifestations of Gnathostomiasis. J Neurol Sci 31:279–291

    Article  PubMed  CAS  Google Scholar 

  • Chotmongkol V, Sawanyawisuth K (2002) Clinical manifestations and outcome of patients with severe eosinophilic meningoencephalitis presumably caused by Angiostrongylus cantonensis. Southeast Asian J Trop Med Public Health 33:231–234

    PubMed  Google Scholar 

  • Chotmongkol V, Sawanyawisuth K, Thavornpitak Y (2000) Corticosteroid treatment of eosinophilic meningitis. Clin Infect Dis 31:660–662

    Article  PubMed  CAS  Google Scholar 

  • Chotmongkol V, Wongjitrat C, Sawadpanit K, Sawanyawisuth K (2004) Treatment of eosinophilic meningitis with a combination of albendazole and corticosteroid. Southeast Asian J Trop Med Public Health 35:172–174

    PubMed  Google Scholar 

  • Dekumyoy P, Komalamisra C, Nuamtanong S, Nacapunchai D, Sinnawong M, Shanaha P, Piyasatittam P (2000) Angiostrongyliasis: analysis of antigens of Angiostrongylus costaricensis adult worms versus IgG from infected patients with Angiostrongylus cantonensis. Southeast Asian J Trop Med Public Health 31(Suppl 1):48–53

    PubMed  Google Scholar 

  • Eamsobhana P, Mak JW, Yong HS (1997) Detection of circulating antigens of Parastrongylus cantonensis in human sera by dot-blot ELISA and sandwich ELISA using monoclonal antibody. Southeast Asian J Trop Med Public Health 28 (Suppl):139–142

    PubMed  Google Scholar 

  • Hwang KP, Chen ER (1998) Larvicidal effect of albendazole against Angiostrongylus cantonensis in mice. Am J Trop Med Hyg 39:191–195

    Google Scholar 

  • Jaroonvesama N, Charoenlarp K, Buranasin P, Zaraspe GG, Cross JH (1985) ELISA testing in cases of clinical angiostrongyliasis in Thailand. Southeast Asian Trop Med Pub Health 16:110–112

    CAS  Google Scholar 

  • Lai SC, Jiang ST, Chen KM, Hsu JD, Shyu LY, Lee HH (2005) Efficacy of albendazole-GM6001 co-therapy against Angiostrongylus cantonensis-induced meningitis in BALB/c mice. Acta Trop 93:267–273

    Article  PubMed  CAS  Google Scholar 

  • Lan KP, Wang CJ, Lai SC, Chen KM, Lee SS, Hsu JD, Lee HH (2004) The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis. Parasitol Res 93:311–317

    Article  PubMed  CAS  Google Scholar 

  • Punyagupta S, Juttijudata P, Bunnag T (1975) Eosinophilic meningitis in Thailand: clinical studies of 484 cases probably caused by Angiostrongylus cantonensis. Am J Trop Med Hyg 24:926–932

    Google Scholar 

  • Sawanyawisuth K, Limpawattana P, Busaracome P, Ninpaitoon B, Chotmongkol V, Intapan PM, Tanawirattananit S (2004) A 1-week course of corticosteroids in treatment of eosinophilic meningitis. Am J Med 117:802–803

    Article  PubMed  Google Scholar 

  • Slom T, Johnson S (2003) Eosinophilic Meningitis. Curr Infect Dis Rep 5:322–328

    Article  PubMed  Google Scholar 

  • Slom TJ, Cortese MM, Gerber SI, Gerber SI, Jones RC, Holtz TH, Lopez AS, Zambrano CH, Sufit RL, Sakolvaree Y, Chaicumpa W, Herwaldt BL, Johnson S (2002) An outbreak of eosinophilic meningitis caused by Angiostrongylus cantonensis in travelers returning from the Caribbean. N Engl J Med 346:668–675

    Article  PubMed  Google Scholar 

  • Tsai HC, Liu YC, Kunin CM, Lee SS, Chen YS, Lin HH, Tsai TH, Lin WR, Huang CK, Yen MY, Yen CM (2001) Eosinophilic meningitis caused by Angiostrongylus cantonensis: report of 17 cases. Am J Med 111:109–114

    Article  PubMed  CAS  Google Scholar 

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Acknowledgment

We would like to thank Professor Kiertjai Bhuripanyo for the study design advice, Assistant Professor Malinee Laopaiboon for statistical advice, SK & F (Thailand) for providing drug and identical placebo and the Grant support by the Faculty of Medicine, Khon Kaen University.

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Correspondence to Kittisak Sawanyawisuth.

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Jitpimolmard, S., Sawanyawisuth, K., Morakote, N. et al. Albendazole therapy for eosinophilic meningitis caused by Angiostrongylus cantonensis . Parasitol Res 100, 1293–1296 (2007). https://doi.org/10.1007/s00436-006-0405-7

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  • DOI: https://doi.org/10.1007/s00436-006-0405-7

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