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Parasitology Research

, Volume 97, Supplement 1, pp S51–S57 | Cite as

Efficacy of a topically administered combination of emodepside and praziquantel against mature and immature Ancylostoma tubaeforme in domestic cats

  • G. Altreuther
  • F. H. M. Borgsteede
  • J. Buch
  • S. D. Charles
  • L. Cruthers
  • C. Epe
  • D. R. Young
  • K. J. Krieger
Original Paper

Abstract

This paper reports the efficacy of emodepside/praziquantel spot–on (Profender®, Bayer AG, Leverkusen, Germany), a novel broadspectrum anthelmintic for dermal application, against L4 larvae and immature adult and adult stages of Ancylostoma tubaeforme in cats. The formulation contains 2.14% (w/w) emodepside and 8.58% (w/v) praziquantel, with emodepside being active against gastrointestinal nematodes and praziquantel against cestodes. Five randomized, blinded and controlled laboratory studies demonstrated 100% efficacy of emodepside/praziquantel spot–on against mature A. tubaeforme and an efficacy of >95% and >97%, respectively, against L4 larvae and immature adults (based on worm counts after necropsy) at approximately the minimum proposed dose rate in cats of 3.0 mg emodepside and 12.0 mg praziquantel/kg body weight. No adverse reactions to the treatment were observed. It is concluded that emodepside/praziquantel spot–on is an effective and safe treatment against infections with mature and immature A. tubaeforme. Emodepside/praziquantel spot–on will considerably facilitate the treatment of cats against nematodes and cestodes compared with orally administered preparations.

Keywords

Praziquantel Gastrointestinal Nematode Emodepside Echinococcus Multilocularis Worm Count 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • G. Altreuther
    • 1
  • F. H. M. Borgsteede
    • 2
  • J. Buch
    • 3
  • S. D. Charles
    • 3
  • L. Cruthers
    • 4
  • C. Epe
    • 5
  • D. R. Young
    • 6
  • K. J. Krieger
    • 1
  1. 1.Bayer HealthCare AGAnimal Health Division, R&D ParasiticidesLeverkusenGermany
  2. 2.Animal Sciences GroupWageningen UR, Division of Infectious DiseasesAB LelystadThe Netherlands
  3. 3.Bayer HealthCare LCCAnimal Health DivisionKansasUSA
  4. 4.Professional Laboratory and Research ServicesCorapeakeUSA
  5. 5.Institute of ParasitologyUniversity of Veterinary MedicineHannoverGermany
  6. 6.Young Veterinary Research ServicesTurlockUSA

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