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Parasitology Research

, Volume 97, Supplement 1, pp S33–S40 | Cite as

Evaluation of the efficacy of emodepside+praziquantel topical solution against cestode (Dipylidium caninum, Taenia taeniaeformis, and Echinococcus multilocularis) infections in cats

  • S. D. Charles
  • G. Altreuther
  • C. R. Reinemeyer
  • J. Buch
  • T. Settje
  • L. Cruthers
  • D. J. Kok
  • D. D. Bowman
  • K. R. Kazacos
  • D. J. Jenkins
  • E. Schein
Original Paper

Abstract

Emodepside+praziquantel topical solution was developed to provide broad–spectrum anthelmintic activity against gastrointestinal parasites in cats. Eight controlled studies were conducted to evaluate the efficacy of a topical solution of emodepside (3 mg/kg) and praziquantel (12 mg/kg) (Profender®, BayerAG, Leverkusen, Germany) against feline infections with three species of cestodes. Studies featured naturally acquired infections of Dipylidium caninum or Taenia taeniaeformis, or experimental infections with Echinococcus multilocularis that were placebo–controlled, randomized and blinded. Cats were euthanatized and necropsied between 2 and 11 days after treatment, depending on the target parasite. The efficacy of emodepside+praziquantel topical solution was 100% against D. caninum and T. taeniaeformis, and 98.5– 100% against E. multilocularis. No significant systemic or local adverse reactions to treatment were noted in cats that received the combination. Topical treatment of cats with emodepside+praziquantel topical solution was safe and highly effective against cestode infections.

Keywords

Praziquantel Emodepside Fecal Examination Echinococcus Multilocularis Alveolar Echinococcosis 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • S. D. Charles
    • 1
  • G. Altreuther
    • 2
  • C. R. Reinemeyer
    • 3
  • J. Buch
    • 1
  • T. Settje
    • 1
  • L. Cruthers
    • 4
  • D. J. Kok
    • 5
  • D. D. Bowman
    • 6
  • K. R. Kazacos
    • 6
  • D. J. Jenkins
    • 7
  • E. Schein
    • 8
  1. 1.Bayer HealthCare LLC, Animal Health DivisionKansasUSA
  2. 2.Bayer HealthCare AGAnimal Health Division, R&D ParasiticidesLeverkusenGermany
  3. 3.East Tennessee Clinical ResearchKnoxvilleUSA
  4. 4.Professional Laboratory Research ServicesUSA
  5. 5.ClinVet InternationalBloemfonteinSouth Africa
  6. 6.Cheri Hill Kennel R & DUSA
  7. 7.School of Botany & ZoologyFaculty of Medicine, Australian National UniversityCanberraAustralia
  8. 8.Freie Universität BerlinInstitute for Parasitology and International Animal HealthBerlinGermany

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