Abstract
Development of Taenia saginata asiatica metacestodes in SCID mice, and its infectivity in humans, golden hamsters, and Mongolian gerbils as alternative definitive hosts, were investigated. Cysticerci were recovered from SCID mice that were subcutaneously injected with hatched oncospheres of T. s. asiatica. The morphological changes of metacestodes were observed. The recovered cysticerci were fed to gerbils, hamsters and humans, to check for their infectivity. Tapeworms were recovered from gerbils and hamsters fed with 20 to 45 week-old cysticerci, and proglottids excretions were observed in human volunteers fed with 45 week-old cysticerci. However, no tapeworms were recovered from gerbils fed with 10 week-old cysticerci. Our results suggest that T. s. asiatica oncospheres needed more than 20 weeks to develop to maturity in SCID mice to be infective to both their natural and alternative definitive hosts.
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Acknowledgements
We thank the staff of Laboratory of Parasitology, Graduate School of Veterinary Medicine, Hokkaido University for their technical support and suggestions. This work was supported in part by a Grant-in Aid for Scientific Research from Japan Society for Promotion of Science and by grants from the Ministry of Health, Labor and Welfare, Japan.
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Chang, S.L., Nonaka, N., Kamiya, M. et al. Development of Taenia saginata asiatica metacestodes in SCID mice and its infectivity in human and alternative definitive hosts. Parasitol Res 96, 95–101 (2005). https://doi.org/10.1007/s00436-005-1328-4
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DOI: https://doi.org/10.1007/s00436-005-1328-4