Abstract
Ivermectin is a member of the macrocyclic lactone family widely used in livestock, pets, and humans as a potent parasiticide. Slight differences in formulation may change the plasma kinetics and efficacy of these compounds. The aim of the study is to evaluate the ability of a liposomal formulation of ivermectin to generate an efficient exposure of the animal to the drug. Ten rabbits were subcutaneously administered with 0.3 mg kg−1 of ivermectin using Ivomec (n=5) or a liposomal formulation (n=5). The areas under serum concentration–time curve were similar after both treatments, indicating the same bioavailability for the two formulations. However, the liposomal formulation gave a higher C max value (33.33 ng ml−1) compared with Ivomec (20.82 ng ml−1) and a significantly faster absorption as indicated by the T max of 0.23 days compared with 1.13 days for the Ivomec formulation. The use of liposomal formulation shows promise as this system improves the efficacy of ivermectin and related drugs.
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We thank Michel Record for helping in liposome preparation.
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Bassissi, F., Lespine, A. & Alvinerie, M. Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration. Parasitol Res 98, 244–249 (2006). https://doi.org/10.1007/s00436-005-0073-z
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DOI: https://doi.org/10.1007/s00436-005-0073-z