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Heterogeneity of class I and class II MHC sequences in Schistosoma mansoni

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Abstract

We investigated the genetic variations in class I and class II major histocompatibility complex (MHC) genes of Schistosoma mansoni and the effects of host MHC genotypes. S. mansoni was maintained in combinations of two mouse strains with different MHC genotypes, and the MHC gene sequences of the cercariae were investigated. The detected class I MHC gene sequences were variable, with high similarity between the H-2Db murine host and the parasite. For other combinations, however, the parasite sequence was homologous to those of anthropoids. All class II MHC sequences detected in S. mansoni were homologous to those of anthropoids. Our results suggest that the genetic variation in the MHC sequences of S. mansoni is derived in part from the current host, indicating horizontal transfer of the sequences from mammal to parasite.

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Acknowledgements

We greatly appreciate the encouragement provided by Dr. Shingo Miura, Forestry and Forest Product Research Institute, and Dr. Seiki Takatsuki, University Museum, University of Tokyo. The cooperation of Ms. Shoko Iida, Ibaraki Prefectural University, is also acknowledged.

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Authors and Affiliations

  1. Center for Arts and Humanities, Ibaraki Prefectural University of Health Sciences, Ami 4669-2, Ami, Inashiki, Ibaraki, 300-0394, Japan

    Ayumi Okada, Atsuko Imase & Yukio Iwamura

  2. Department of Tropical Medicine and Parasitology, Dokkyo University School of Medicine, Mibu, Tochigi, 321-0293, Japan

    Hajime Matsuda

  3. Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 300-0394, Japan

    Hiroshi Ohmae

  4. Institute of Experimental Animal Research, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan

    Hidekazu Hata

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  1. Ayumi Okada
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  2. Atsuko Imase
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  3. Hajime Matsuda
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  4. Hiroshi Ohmae
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  5. Hidekazu Hata
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  6. Yukio Iwamura
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Correspondence to Yukio Iwamura.

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Okada, A., Imase, A., Matsuda, H. et al. Heterogeneity of class I and class II MHC sequences in Schistosoma mansoni . Parasitol Res 99, 21–27 (2006). https://doi.org/10.1007/s00436-005-0035-5

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  • DOI: https://doi.org/10.1007/s00436-005-0035-5

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