Abstract
The in vitro antimalarial activity against Plasmodium falciparum and heme polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC50) ranging from 15.5 μM to 190 μM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.
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Acknowledgement
This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (13226079 and 14021072) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
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Begum, K., Kim, HS., Kumar, V. et al. In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum . Parasitol Res 90, 221–224 (2003). https://doi.org/10.1007/s00436-003-0830-9
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DOI: https://doi.org/10.1007/s00436-003-0830-9