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Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation

Abstract

To investigate the effects of acute fecal peritonitis on plasma and tissue lipid peroxidation and possible protective effects of vitamin E (Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups were designated as: controls, peritonitis, Vit E and cimetidine. Plasma, liver, lung and kidney thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elevation in liver TBARS; however, neither Vit E nor cimetidine was effective in preventing TBARS formation. Administration of Vit E and cimetidine caused significant decrements from the peritonitis value in liver and lung CD levels.

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Tuncel, P., Gür, E.S., Kaya, E. et al. Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation. Res. Exp. Med. 197, 235–241 (1997). https://doi.org/10.1007/s004330050072

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  • DOI: https://doi.org/10.1007/s004330050072

Key words

  • Fecal peritonitis
  • Conjugated dienes
  • TBARS
  • Vitamin E
  • Cimetidine