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Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation

Research in Experimental Medicine volume 197, pages 235–241 (1997)Cite this article

Abstract

To investigate the effects of acute fecal peritonitis on plasma and tissue lipid peroxidation and possible protective effects of vitamin E (Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups were designated as: controls, peritonitis, Vit E and cimetidine. Plasma, liver, lung and kidney thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elevation in liver TBARS; however, neither Vit E nor cimetidine was effective in preventing TBARS formation. Administration of Vit E and cimetidine caused significant decrements from the peritonitis value in liver and lung CD levels.

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Authors and Affiliations

  1. Department of Biochemistry, Uludag University Faculty of Medicine, Bursa, Turkey

    Pınar Tuncel, Esma Sürmen Gür, Resul Özbek & Ercan Öztürk

  2. Department of Surgery, Uludag University Faculty of Medicine, Bursa, Turkey

    Ekrem Kaya & Rıfat Tokyay

Authors
  1. Pınar Tuncel
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  2. Esma Sürmen Gür
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  3. Ekrem Kaya
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  4. Resul Özbek
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Tuncel, P., Gür, E.S., Kaya, E. et al. Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation. Res. Exp. Med. 197, 235–241 (1997). https://doi.org/10.1007/s004330050072

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  • DOI: https://doi.org/10.1007/s004330050072

Key words

  • Fecal peritonitis
  • Conjugated dienes
  • TBARS
  • Vitamin E
  • Cimetidine