Skip to main content
SpringerLink
Log in

Effects of chronic cigarette smoke inhalation on the development of senile lung in senescence-accelerated mouse

  • Published:
Research in Experimental Medicine

Abstract

The senescence-accelerated mouse (SAM) manifests most of the features of function and morphology in the senile lung with aging. However, little is known about the effects of age and cigarette smoke on alterations of the lung in SAM. In the present study, we examined the effects of chronic cigarette smoke inhalation and age on the function and morphology of lungs in two strains of SAM, SAMP2 (senescence-prone strain) and SAMR1 (senescence-resistant strain), from 6 months of age (young) and 18 months of age (aged). After 4 weeks of cigarette smoke inhalation, a small but significant airspace along with a leftward shift of the pressure-volume (P-V) curve was observed in young SAMP2, but not in SAMR1. However, the airspace size of young SAMP2 with cigarette inhalation was smaller than that in aged SAM with air inhalation, suggesting that the effect of age may be greater than that of the small burder of tobacco smoke on the lung alterations in SAMP2. In the aged SAM, there were no differences in function and structure between tobacco-exposed and air-exposed mice. Because the changes in the lungs of young SAMP2 exposed to cigarette smoke were partly simulated with age-related alterations in human lung, and because age-dependent changes of lungs were clearly investigated in SAMP2, this strain may be an interesting animal model for investigating the effects of age and/or cigarette smoke on alterations in lung structure and function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Begin RO, Filon R, Ostiguy G (1995) Emphysema in silica- and asbestos-exposed workers seeking compensation: a CT scan study. Chest 108:647–655

    Article  CAS  PubMed  Google Scholar 

  2. Campbell T, Tomkeieff SI (1952) Calculation of the internal surface area of a lung. Nature 170:116–117

    Article  CAS  PubMed  Google Scholar 

  3. Chretien J (1989) Pollution (atmospheric, domestic, and occupational) as a risk factor for chronic airways disease. Chest 96[Suppl]:S316–S317

    Article  Google Scholar 

  4. Cohen BH, Ball WC, Bias WB (1975) A genetic epidemiologic study of chronic obstructive pulmonary disease: study design and preliminary observation. Johns Hopkins Med J 137:94–104

    Google Scholar 

  5. Colebatch HJH, Ng CKY, Nikov N (1979) Use of an exponential function for elastic recoil. J Appl Physiol 46:387–393

    CAS  PubMed  Google Scholar 

  6. Colebatch HJH, Greaves IA, Ng CKY (1979) Exponential analysis of elastic recoil and aging in healthy males and females. J Appl Physiol 47:683–691

    CAS  PubMed  Google Scholar 

  7. Crofton J, Masironi R (1989) Chronic airway disease: the smoking component. Chest 96[Suppl]:S349–S355

    Google Scholar 

  8. Crystal RG (1990) Alpha1-antitrypsin deficiency, emphysema, and liver disease. J Clin Invest 150:1343–1352

    Article  Google Scholar 

  9. Habar PS, Colebatch HJH, Ng CKY, Greaves IA (1983) Alveolar size as a determination of pulmonary distensibility in mammalian lungs. J Appl Physiol 54:837–845

    Google Scholar 

  10. Janoff A, Carp H, Lee DK (1979) Cigarette smoke inhalation decreases alpha1-antitrypsin activity in rat lung. Science 206:1313–1314

    Article  CAS  PubMed  Google Scholar 

  11. Janoff A (1985) Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis. Am Rev Respir Dis 132:417–433

    CAS  PubMed  Google Scholar 

  12. Kalandidi A, Trichopoulos D, Hatzakis A et al. (1987) Passive smoking and chronic obstructive lung disease. Lancet II:1325–1326

    Article  Google Scholar 

  13. Kawakami M, Paul JL, Thurlbeck WM (1984) The effect of age on lung structure in male BALB/cNNia inbred mice. Am J Anat 170:1–21

    Article  CAS  PubMed  Google Scholar 

  14. Kerr JS, Yu SY, Riley DJ (1989) Strain-specific respiratory air space enlargement in aged rats. Exp Gerontol 25:563–574

    Article  Google Scholar 

  15. Kitada H, Higuchi K, Takeda T (1994) Molecular characterization of the senescence-accelerated mouse (SAM) strains.J Gerontol 49:B247–B254

    Article  Google Scholar 

  16. Knudson RJ, Clark DF, Kennedy TC, Knudson DF (1977) Effect of aging along on mechanical properties of the normal adult human lung. J Appl Physiol 43:1054–1062

    CAS  PubMed  Google Scholar 

  17. Mittman C, Edelman NH, Norris AH, Schock NW (1965) Relationship between chest wall and pulmonary compliance and age. J Appl Physiol 20:1211–1216

    Google Scholar 

  18. Mizuuchi T, Kida K, Fujino Y (1994) Morphological studies of growth and aging in the lungs of Fischer 344 male rats. Exp Gerontol 29:553–567

    Article  CAS  PubMed  Google Scholar 

  19. Osborne S, Hogg JC, Wright JL, Coppin C, Pare PD (1988) Exponential analysis of the pressure-volume curve: correlation with mean linear intercept and emphysema in human lungs. Am Rev Respir Dis 137:1083–1088

    Article  CAS  PubMed  Google Scholar 

  20. Pump KK (1968) The aged lung. Chest 60:571–577

    Article  Google Scholar 

  21. Sahebjami H (1991) Lung tissue elasticity during the lifespan of Fisher 344 rats.Exp Lung Res 17:887–902

    Article  CAS  PubMed  Google Scholar 

  22. Sahebjami H (1993) Mini-review: nutrition and lung structure and function.Exp Lung Res 19:105–124

    Article  CAS  PubMed  Google Scholar 

  23. Snider GL, Kleinerman J, Thurlbeck WN (1985) Bengali 2: the definition of emphysema: report of a National Heart, Lung, and Blood Institute, Division of Lung Disease Workshop.Am Rev Respir Dis 132:182–185

    Google Scholar 

  24. Snider GL (1992) Emphysema: the first two centuries and beyond. A historical overview, with suggestions for future research (two parts). Am Rev Respir Dis 146:1334–1344, 1615–1622

    Article  CAS  PubMed  Google Scholar 

  25. Tager IB, Speizer FE (1976) Risk estimates for chronic bronchitis in smokers: a study of male-female differences. Am Rev Respir Dis 113:619–625

    CAS  PubMed  Google Scholar 

  26. Takeda T, Hosokawa M, Higuchi K (1991) Senescence-accelerated mouse (SAM): a novel murine model of accelerated senescence. J Am Geriatr Soc 39:911–919

    CAS  PubMed  Google Scholar 

  27. Thurlbeck WM (1995) Chronic airflow obstruction. In: Thurlbeck WM, Churg AM (eds) Pathology of the lung. Thieme, New York, pp 780–825

    Google Scholar 

  28. Turner JM, Mead J, Wohl ME (1968) Elasticity of human lungs in relation to age.J Appl Physiol 25:664–671

    CAS  PubMed  Google Scholar 

  29. Teramoto S, Fukuchi Y, Uejima Y, Ito H, Orimo H (1992) Age-related changes in GSH content of eyes in mice — a comparison of senescence accelerated mouse (SAM) and C57BL/J mice.Comp Biochem Physiol 102A:693–696

    CAS  Google Scholar 

  30. Teramoto S, Fukuchi Y, Uejima Y, Teramoto K, Orimo H (1993) Influences of chronic tobacco smoke inhalation on aging and oxidant-antioxidant balance in senescence accelerated mouse (SAM)-P/2.Exp Gerontol 28:87–95

    Article  CAS  PubMed  Google Scholar 

  31. Teramoto S, Fukuchi Y, Uejima Y, Teramoto K, Oka T, Orimo H (1994) A novel model of senile lung: senescence-accelerated mouse (SAM).Am J Respir Crit Care Med 150:238–244

    Article  CAS  PubMed  Google Scholar 

  32. Teramoto S, Fukuchi Y, Nagase T, Matsuse T, Orimo H (1995) Comparison of ventilation components between young and elderly men during exercise.J Gerontol (Biol Sci) 50A:B34–B39

    Article  CAS  Google Scholar 

  33. Teramoto S, Fukuchi Y, Ueyima Y, Teramoto K, Orimo H (1995) Biochemical characteristics of senescence-accelerated mouse (SAM).Eur Respir J 8:450–456

    Article  CAS  PubMed  Google Scholar 

  34. Uejima Y, Fukuchi Y, Nagase T, Matsuse T, Yamaoka Y, Orimo H (1990) Influences of inhaled tobacco smoke on senescence-accelerated mouse (SAM). Eur Respir J 3:1029–1036

    CAS  PubMed  Google Scholar 

  35. Uejima Y, Fukuchi Y, Nagase T, Tabata R, Orimo H (1991) A new murine model of aging lung: the senescence accelerated mouse (SAM)-P.Mech Ageing Dev 61:223–236

    Article  CAS  PubMed  Google Scholar 

  36. Verbeken EK, Cauberghs M, Mertens I, Clement J, Lauweryns JM, Van de Woestijne KP (1992) The senile lung: comparison with normal and emphysematous lungs. Structural aspects. Chest 101:793–799

    Article  CAS  PubMed  Google Scholar 

  37. Verbeken EK, Cauberghs M, Mertens I, Clement J, Lauweryns JM, Van de Woestijne KP (1992) The senile lung: comparison with normal and emphysematous lungs. Functional aspects. Chest 101:800–809

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Geriatrics, Faculty of Medicine, 7-3-1, Hongo Bunkyo-ku, Tokyo, Japan, 113

    Shinji Teramoto, Kazuko Teramoto, Takeshi Matsuse, Yasuyoshi Ouchi & Yoshinosuke Fukuchi

  2. Pharmaceutical Discovery Research Laboratories, Teijin Institute for Bio-medical Research, Teijin Ltd., Hino, Japan

    Yasuhide Uejima

  3. Department of Pathology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    Teruaki Oka

Authors
  1. Shinji Teramoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasuhide Uejima
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Teruaki Oka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kazuko Teramoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takeshi Matsuse
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yasuyoshi Ouchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yoshinosuke Fukuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Teramoto, S., Uejima, Y., Oka, T. et al. Effects of chronic cigarette smoke inhalation on the development of senile lung in senescence-accelerated mouse. Res. Exp. Med. 197, 1–11 (1997). https://doi.org/10.1007/s004330050050

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004330050050

Key words

Search

Navigation