Abstract
We have carried out a detailed analysis of the cellular immune functions of breast cancer patients in comparison with healthy controls. A possible correlation between immune and clinical parameters was analysed in 50 breast cancer patients. Immune parameters, natural killer cell and T lymphocyte functions and the numbers of circulating T lymphocytes were analysed against the clinical parameters comprising the tumour burden, the stage of the disease and the expression of hormone receptors on the tumour. In order to analyse the immune function data effectively, low responders were identified with stringent cut-off values. Considerably higher proportions of low responders were found among the patient population. Elevated numbers of circulating T lymphocytes and CD3-directed cytolysis correlated with the expression of oestrogen receptors independently of the clinical/histological parameters.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 11 September 1998 / Accepted: 7 December 1998
Rights and permissions
About this article
Cite this article
Shevde, L., Joshi, N., Dudhat, S. et al. Immune functions, clinical parameters and hormone receptor status in breast cancer patients. J Cancer Res Clin Oncol 125, 313–320 (1999). https://doi.org/10.1007/s004320050280
Issue Date:
DOI: https://doi.org/10.1007/s004320050280