Abstract
Introduction
Hedgehog Signaling, a basic cancer stem cell pathway, plays a major role during the embryonic development, is known to play a quiescent role in adults. However, aberrant activation of Hedgehog signaling in adults is known to play a role in cancer development. Hence, the aim of the study was to identify the role of Hedgehog signaling pathway in the Oral cancers.
Materials and Methods
The expression of Hedgehog signaling pathway was evaluated in 124 patients through the quantitative real-time PCR. The association between the gene expression and clinico-pathological parameters were analyzed using the Pearson chi-square test and survival analysis was carried out using Kaplan-Meier analysis.
Results
SHH and GLI1 was found to be significantly associated with the Lymph Node Status and SUFU was significantly associated with the Age. SMO and SUFU were found to have a worse prognosis in oral cancer patients. According to our findings, IHH plays a critical role in the activation of the HH signaling pathway in oral cancer.
Conclusion
These findings back up the use of the Hedgehog signaling pathway as a biomarker for early disease prediction in oral cancer, as well as its role in tumor aggressiveness and invasiveness.
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Data Availability
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request and with the prior permission from the institute.
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Acknowledgements
Hitarth Patel is PhD student of Life science (Faculty of Science), Gujarat University working at The Gujarat Cancer & Research Institute. Dr Franky D. Shah is a recognized PhD Supervisor of Life Science (Faculty of Science), Gujarat University working at The Gujarat Cancer & Research Institute.
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Study Concept - FDS; Study Design - FDS; Data Acquisition - HVP; Data Analysis and Interpretation - HVP, JSJ; Statistical Analysis: HVP, JSJ; Manuscript Preparation: HVP; Manuscript Editing: FDS; Manuscript Review: FDS.
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Patel, H.V., Joshi, J.S. & Shah, F.D. A clinicopathological exploration of Hedgehog signaling: implications in oral carcinogenesis. J Cancer Res Clin Oncol 149, 16525–16535 (2023). https://doi.org/10.1007/s00432-023-05383-w
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DOI: https://doi.org/10.1007/s00432-023-05383-w