Abstract
Purpose
Urothelial carcinoma (UC) of the bladder (BUC) and the upper urinary tract (UTUC) are the two most common UCs. The incidence of UTUC in Taiwan is the highest worldwide. Aristolochic acid (AA) was identified as the main cause of UTUC in Taiwan. To explore trends in the incidence of UC in Taiwan after the ban on Chinese herbal preparations containing AA in 2003.
Methods
We used data from the Taiwanese National Health Insurance Research Database–linked Taiwanese National Cancer Registry for 2001–2018. UC was defined in accordance with the International Classification of Disease for Oncology. The age-standardized incidence was calculated on the basis of the World Health Organization standard population. Trends in the incidence were calculated as the annual percent change (APC) by using the Joinpoint regression program.
Results
Over the investigated period, the incidence of UC decreased at an average annual percent change (AAPC) of − 1.19% (95% CI − 1.47 ~ − 0.91, P < 0.001). However, the incidence in UTUC significantly increased, with the AAPC being 1.47% (95% CI 1.03 ~ 1.90, P < 0.001). In contrast, the incidence of BUC significantly decreased, with the overall AAPC being − 1.92% (95% CI − 2.3 ~ − 1.54, P < 0. 001). From 2001 to 2018, the overall incidence of UCs and BUC decreased in Taiwan, but the incidence of UTUC significantly increased.
Conclusion
We suggest to apply the same review standards of new drug development process to herbal preparations and incorporate them into the adverse drug reaction or poison surveillance system. Most importantly, raise public awareness of the potential toxicity of phytotherapy.
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Data availability
All data generated or analysed during this study are included in this article and its supplementary material files. Further enquiries can be directed to the corresponding author.
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Acknowledgements
We thank the National Health Insurance Administration and Health and Welfare Data Science Center, Ministry of Health and Welfare, for providing data and the Institute of Population Health Sciences, National Health Research Institutes, for supporting this study.
Funding
This work was supported by grants (VGHKS111-142 to CIL, VGHKS111-174 to KJC) from Kaohsiung Veterans General Hospital.
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K-JC and C-IL conceived the study concept and designed the study. C-IL, H-CF, C-TT and K-JC conducted material preparation, data collection, analysis and generated figures and tables. C-IL, H-CF and K-JC wrote the manuscript. P-TL, C-YH, C-LC, C-WH, X-YC, and S-HO provided important intellectual content to the manuscript. All authors have read and approved the final manuscript.
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This study was approved by the Institutional Review Board of Kaohsiung Veterans General Hospital Research Ethics Committee (KSVGH20- EM 1-01). Informed consent of the study participants was waived as this study used deidentified administrative data.
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Liao, CI., Fang, HC., Lee, PT. et al. Trends in the incidence of urothelial carcinoma in Taiwan after the ban on aristolochic acid-containing Chinese herbal preparations, 2001–2018: a national population-based cohort study. J Cancer Res Clin Oncol 149, 8201–8211 (2023). https://doi.org/10.1007/s00432-023-04771-6
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DOI: https://doi.org/10.1007/s00432-023-04771-6