Abstract
Purpose
Surgical resection is cornerstone treatment for early-stage non-small cell lung cancer (NSCLC) and offers a chance for cure. This study was conducted to determine current surgical treatment patterns and outcomes of Chinese patients with NSCLC.
Methods
Data of patients with histologically confirmed NSCLC of stages IA–IIIA and who underwent surgery between July 2014 and July 2020 were retrospectively collected from 9 tertiary hospitals in China. Cox model was used for multivariate analyses.
Results
This study included 11,958 patients, among whom 59.1%, 19.2%, and 21.7% were in stages I, II, and IIIA, respectively. Lobectomy was the most common operation method (78.4%), followed by wedge resection (8.2%), segmentectomy (5.4%), pneumonectomy (5.2%), and bronchial sleeve lobectomy (2.8%). Among patients who underwent wedge resection and segmentectomy, majority had stage I NSCLC (87.2% and 93.3%, respectively), and sublobectomy accounted for 20.7% of stage I operations. With a median follow-up time of 30.2 months, disease-free survival (DFS) and overall survival (OS) rates of entire population were 88.9% and 96.1% at 1 year, 75.2% and 85.1% at 3 years, and 65.3% and 77.0% at 5 years, respectively. The 5-year OS rates for stages IA, IB, IIA, IIB, and IIIA disease were 93.2%, 82.7%, 70.3%, 67.0%, and 52.1%, respectively.
Conclusion
This is the largest real-world cohort study of patients with NSCLC who underwent surgery in China, where we described characteristics of surgical treatment and survival outcomes. The results of our study provide insights into real-world surgical treatment status for surgeons and clinicians.
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Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Acknowledgements
The authors thank the study participants and investigators for their participation. Technical support for this work was provided by LinkDoc Inc., and the authors thank Liu Jie, Chen Zijia, and Tang Lang for their support in data curation, statistical analysis, and data interpretation.
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All authors contributed to the study conception and design. SD, HJ: Writing and experimental design; Data collection, curation, and putting forward modification opinions. CP: Statistical guidance. LX: Data collection, curation, and putting forward modification opinions. HeJianxing: Data collection, curation, and putting forward modification opinions. XL: Data collection, curation, and putting forward modification opinions. FX: Data collection, curation, and putting forward modification opinions. LY: Data collection, curation, and putting forward modification opinions. LD: Data collection, curation, and putting forward modification opinions. ZX: Data collection, curation, and putting forward modification opinions. LL: Experimental design conceptualization and finalizing the article.
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Daqiang Sun, Jian Hu, Xiaofei Li, Jianxing He, Lin Xu, Xiangning Fu, Yang Liu, Deruo Liu, Pingyan Chen, Xun Zhang, and Lunxu Liu declare no conflict of interest.
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This study was approved by the medical ethics committee of the Tianjin Chest Hospital (institutional review board number, 2021-LW-001) and was conducted in accordance with the Good Clinical Practice and the Declaration of Helsinki and its latest amendments.
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Sun, D., Hu, J., Li, X. et al. Real-world surgical treatment patterns and clinical outcomes in patients with stages IA–IIIA non-small cell lung cancer: a retrospective multicentric observational study involving 11,958 patients. J Cancer Res Clin Oncol 149, 8213–8223 (2023). https://doi.org/10.1007/s00432-023-04729-8
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DOI: https://doi.org/10.1007/s00432-023-04729-8