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The role of systemic inflammatory response index (SIRI) and tumor-infiltrating lymphocytes (TILs) in the prognosis of patients with laryngeal squamous cell carcinoma

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Abstract

Objective

Systemic inflammatory response index (SIRI) values and tumor-infiltrating lymphocytes (TILs) are associated with the prognosis of various tumors. There is minimal evidence of those two as prognostic markers in laryngeal squamous cell carcinoma (LSCC). In this study, we aimed to examine the predictive value of SIRI and tumor-infiltrating CD3+/CD4+/CD8+ T cells in the prognosis of patients who underwent partial or total laryngectomy.

Study design

A total of 78 patients with LSCC who underwent total or partial laryngectomy at the Eye, Ear, Nose, and Throat Hospital of Fudan University between 2013 and 2015 were retrospectively analyzed.

Methods

The tumor tissues of 78 LSCC patients were retrospectively evaluated using immunohistochemical staining for CD3+ /CD4+ /CD8+ -cells. The overall survival (OS) and disease-free survival (DFS) rates were recorded using the Kaplan–Meier method.

Results

Patients with high immunoscore (IS) (3–4) had prolonged survival (P < 0.001 for OS). High SIRI values were independently associated with poorer OS and DFS (P = 0.018 for OS; P = 0.016 for DFS). CD8+ TILs and SIRI values showed a- negative association (P < 0.01). Patients with low SIRI values and high IS had better 5-year OS and DFS than those with high SIRI values and low IS (P < 0.001 for OS; P = 0.0014 for DFS). Patients with ‘hot’ tumor had a higher 5-year OS than those with ‘excluded’ or ‘cold’ phenotype.

Conclusions

The SIRI values and the density of TILs may help predict LSCC patients' outcomes after surgery. The combination of SIRI and IS may be a new component of the tumor, nodes, and metastases (TNM) classification of cancer and prognostic factor for T-cell-target immunotherapy.

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Funding

This study was supported by Clinical Research Plan of SHDC (No. SHDC2020CR6011), the Science and Technology Commission of Shanghai Municipality under Grant (16411950100), the National Natural Science Foundation of China (82203506, 82103316, 81772878, 30972691), and the Shanghai Municipal Science and Technology Foundation under Grant (11JC1410802).

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Author notes

  1. Tian Wang and Duo Zhang have contributed equally to this work.

Authors and Affiliations

  1. Department of Otolaryngology–HNS, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University School of Medicine, 83 Fenyang Road, Shanghai, 200031, People’s Republic of China

    Tian Wang, Duo Zhang, Di Tang, Yu Heng & Lei Tao

  2. Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Shanghai, 200025, People’s Republic of China

    Li-ming Lu

Authors
  1. Tian Wang
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  2. Duo Zhang
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  4. Yu Heng
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Contributions

Tian Wang, Duo Zhang, and Lei Tao: Study concepts and study design. Tian Wang and Di Tang: Data acquisition. Tian Wang, Duo Zhang, and Li-ming Lu: Data analysis and interpretation. Tian Wang and Yu Heng: Statistical analysis. Tian Wang and Duo Zhang: Manuscript preparation. Tian Wang and Duo Zhang: Manuscript editing. Li-ming Lu and Lei Tao: Manuscript review.

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Correspondence to Li-ming Lu or Lei Tao.

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Wang, T., Zhang, D., Tang, D. et al. The role of systemic inflammatory response index (SIRI) and tumor-infiltrating lymphocytes (TILs) in the prognosis of patients with laryngeal squamous cell carcinoma. J Cancer Res Clin Oncol 149, 5627–5636 (2023). https://doi.org/10.1007/s00432-022-04469-1

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