Abstract
Purpose
Endometrial cancer in recent years has taken the lead among cancer processes of the female reproductive system. The feasibility of pelvic and para-aortic lymph node dissection in patients with endometrial cancer has always been a controversial issue. The aim of the presented paper is to evaluate the feasibility of pelvic and para-aortic lymph node dissection in patients with endometrial cancer, depending on the stage of the disease, postoperative complications, and patient survival, depending on the volume of surgical intervention.
Methods
The study involved 285 patients with stages of I–IV endometrioid endometrial cancer of the Pre-graduate Department of Oncogynecology of the National Cancer Institute. The average age of patients was 55 ± 5.7 years. In 74.5%, the disease was detected at stage I and uterine extirpation was performed with/without appendages.
Results
The duration of the operation varies depending on the volume of intervention—from 1 h 30 min ± 10 min for panhysterectomy, up to 3 h 20 min ± 10 min when performing para-aortic lymph node dissection. The average number of lymph nodes removed was—7 ± 1.1 pelvic and 12 ± 1.5 para-aortic.
Conclusion
The basic principles of surgical treatment consist in individual choice of the scope of surgical intervention, performing adequate lymph node dissection, and preventing relapse and metastasis of the disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Data availability
The data that support the findings of this study are available from the corresponding author on reasonable request.
Change history
22 March 2024
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s00432-024-05690-w
References
American College of Obstetricians and Gynecologists (2018) ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2018: Management of endometrial cancer. Obstet Gynecol 106(2):413–425. https://doi.org/10.1097/00006250-200508000-00050
Amanta F, Mirzab M, Creutzbergc C (2018) FIGO cancer report 2015. Cancer of the corpus uteri. Intern J of Gynec Obst 143(2):37–50
American Joint Committee on Cancer. Corpus Uteri-Carcinoma and Carcinosarcoma (2017). https://doi.org/10.3322/caac.21388
Bersimbaev R, Bulgakova O, Aripova A, Kussainova A, Ilderbayev O (2021) Role of microRNAs in lung carcinogenesis induced by asbestos. J Pers Med 11(2):1–23
Bolliger M, Kroehnert AJ, Molineus F, Kandioler D, Schindl M, Riss P (2018) Experiences with the standardized classification of surgical complications (Clavien-Dindo) in general surgery patients. Europ Surg 50:256–261
Bray F, Ferlay J, Soerjomataram I (2018) Global cancer statistics 2018 GLOBOCAN estimates of incidence and mortality worldwide for cancers in countries. CA A Cancer J Clinic 68(6):394–424
Colombo N, Creutzberg C, Amant F (2016) ESMO-ESGO-ESTRO consensus conference on endometrial cancer. Diagnosis treatment and follow-up. Intern J of Gynec Cancer 26(1):2–30
Egemann H, Ignatov T, Kaiser K (2016) Survival of lymphadenectomy in endometrial cancer. J of Cancer Res Clin Oncol 142:1051–1060
Fedorenko ZP, Gulak LO, Mikhailovich YY, Gorokh EL, Ryzhov AY, Sumkina OV, Kutsenko LB (2020) Cancer in Ukraine Morbidity, mortality, indicators of oncology service. www.ncru.inf.ua/publications/
Kim M, Choi C, Kim K, Lim MC, Park JY, Hong JH, Lee M, Paek J, Seoung J, Lee S (2018) Three-year recurrence-free survival in patients with a very low risk of endometrial cancer who did not undergo lymph node dissection (tree retro): A Korean multicenter study. Intern J of Gynec Cancer 28(6):1123–1129
Li L, Mingming T, Dan N, Jinhai G, Zhengyu L (2020) Para-aortic lymphadenectomy did not improve overall survival among women with type I endometrial cancer. Intern J of Gynec Obst 150(2):163–168
Polaka I, Bhandari MP, Mezmale L, Anarkulova L, Veliks V, Sivins A, Lescinska AM, Tolmanis I, Vilkoite I, Ivanovs I, Padilla M, Mitrovics J, Shani G, Haick H, Leja M (2022) Modular point-of-care breath analyzer and shape taxonomy-based machine learning for gastric cancer detection. Diagnostics 12(2):491
Seagle BL, Kocherginsky M, Shahabi S (2017) Association of pelvic and para-aortic lymphadenectomy with survival in stage I endometrioid endometrial cancer: Matched cohort analyses from the national cancer database. JCO Clin Cancer Inform 1:1–14
Toptas T, Simsek T (2015) Survival analysis only after pelvic lymphadenectomy compared with combined pelvic and para-aortic lymphadenectomy in patients with endometrial endometrial cancer. Oncol Lett 9(1):355–364
Turkler C, Kulhan M, Kulhan N, Ata N, Sanci M, Ozeren M (2018) Role of lymphadenectomy in disease-free and overall survival on low-risk endometrium cancer patients. Ginekol Polska 89(6):311–315
Watari H, Katayama H, Shibata T, Ushijima K, Satoh T, Onda T (2017) Phase III trial to confirm the superiority of pelvic and para-aortic lymphadenectomy to pelvic lymphadenectomy alone for endometrial cancer: Japan clinical oncology group study 1412 (SEPAL-P3). Japan J of Clinic Oncol 47:986–990
Working group for gynecological oncology (2020). https://clinicaltrials.gov/ct2/show/NCT03438474.
Funding
None.
Author information
Authors and Affiliations
Contributions
OM and VS participated in study design and drafted the manuscript. OM performed the data curation and analysis. VS contributed to visualisation. OM and VS contributed for overall editing and supervision. All the authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no conflict of interests.
Ethical approval
All the procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Consent to participate
The patients provided their written informed consent to participate in this study.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s00432-024-05690-w"
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Movchan, O., Svintsitskyi, V. RETRACTED ARTICLE: The role of lymph node dissection in the surgical treatment of endometrial cancer patients (retrospective analysis). J Cancer Res Clin Oncol 149, 63–68 (2023). https://doi.org/10.1007/s00432-022-04406-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00432-022-04406-2