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Statins and the risk of gastric, colorectal, and esophageal cancer incidence and mortality: a cohort study based on data from the Korean national health insurance claims database

Abstract

Background

This study investigated the association between the use of statins, the incidence of gastric, colorectal, and esophageal cancers, and mortality between January 2005 and June 2013 in South Korea.

Methods

We compared patients aged 45–70 years statin users for at least 6 months to non-statin users matched by age and sex, from 2004 to June 2013 using the National Health Insurance database. Main outcomes were gastric, colorectal, and esophageal cancer incidence and mortality. Cox proportional hazard regression was used to calculate the adjusted hazard ratios (aHRs) and 95% confidence intervals (95% CIs) among overall cohort and matched cohort after propensity score matching with a 1:1 ratio.

Results

Out of 1,008,101 people, 20,473 incident cancers, 3938 cancer deaths occurred and 7669 incident cancer, 1438 cancer death in matched cohort. The aHRs for the association between the risk of cancers and statin use were 0.7 (95% CI 0.65–0.74) for gastric cancer, 0.73 (95% CI 0.69–0.78) for colorectal cancer, and 0.55 (95% CI 0.43–0.71) for esophageal cancer. There were associations between statin use and decreased gastric cancer mortality (HR 0.46, 95% CI 0.52–0.57), colorectal cancer mortality (HR 0.43, 95% CI 0.36–0.51), and esophageal cancer mortality (HR 0.41, 95% CI 0.27–0.50) in the overall cohort and this pattern was similar in the matched cohort.

Discussion

Statin use for at least 6 months was significantly associated with a lower risk of stomach, colorectal, and esophageal cancer incidence as well as cancer mortality after a diagnosis.

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Acknowledgements

Not applicable.

Funding

We received no funding for this work.

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Authors and Affiliations

Authors

Contributions

DSK and HA participated in conceptualization. DSK performed data curation and formal analysis. DSK and HK wrote original draft. HK and HA edited the manuscript.

Corresponding author

Correspondence to Hyeong Sik Ahn.

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Conflict of interest

We declare any competing financial/or non-financial interests.

Ethics approval and consent to participate

The study was performed in accordance with the Declaration of Helsinki. The ethics approval and consent from the participants was waived, because this study used anonymous database.

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Kim, Ds., Kim, H.J. & Ahn, H.S. Statins and the risk of gastric, colorectal, and esophageal cancer incidence and mortality: a cohort study based on data from the Korean national health insurance claims database. J Cancer Res Clin Oncol 148, 2855–2865 (2022). https://doi.org/10.1007/s00432-022-04075-1

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  • DOI: https://doi.org/10.1007/s00432-022-04075-1

Keywords

  • Statin
  • Gastric cancer
  • Colorectal cancer
  • Esophageal cancer
  • Incidence
  • Mortality