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Oncological outcomes of squamous cell carcinoma of the cervical esophagus treated with definitive (chemo-)radiotherapy: a systematic review and meta-analysis

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

To determine the oncological outcomes of cervical esophageal squamous cell carcinoma (CESCC) treated with definitive chemoradiotherapy (CRT).

Methods

A systematic review and meta-analysis was performed according to the PRISMA guidelines.

Results

A total of 1222 patients (median age: 63.0 years, 95% CI 61.0–65.0) were included from 22 studies. The median follow-up time was 34.0 months (n = 1181, 95% CI 26.4–36.0). Estimated pooled OS rates (95% CI) at 1, 3, and 5 years were 77.9% (73.9–82.2), 48.4% (43.2–54.3), and 35.3% (29.7–41.9), respectively. The median OS (95% CI) was 33.4 months (25.8–42.2). Estimated pooled PFS rates (n = 595; 95% CI) at 1, 3, and 5 years were 64.1% (57.9–71.0), 38.0% (33.3–45.5), and 29.8% (23.9–37.1), respectively. The median PFS (95% CI) was 19.8 months (14.9–26.6).

Conclusions

Definitive CRT is a valuable first-line treatment for the management of CESCC. Further studies should focus on survival predictors able to define stage-based clinical guidelines.

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Data availability

Data and material are available on request.

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Author notes

  1. Armando De Virgilio and Andrea Costantino contributed equally.

  2. Carlo Castoro and Giuseppe Spriano contributed equally.

Authors and Affiliations

  1. Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele, Milan, Italy

    Armando De Virgilio, Andrea Costantino, Bianca Maria Festa, Giuseppe Mercante, Ciro Franzese, Marta Scorsetti, Carlo Castoro & Giuseppe Spriano

  2. Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy

    Armando De Virgilio, Andrea Costantino, Bianca Maria Festa, Giuseppe Mercante & Giuseppe Spriano

  3. Radiotherapy Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy

    Davide Franceschini, Ciro Franzese & Marta Scorsetti

  4. Oncology Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy

    Andrea Marrari & Raffaele Cavina

  5. Division of Upper Gastrointestinal Surgery, Department of Surgery, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy

    Salvatore Marano & Carlo Castoro

Authors
  1. Armando De Virgilio
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  2. Andrea Costantino
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Correspondence to Andrea Costantino.

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De Virgilio, A., Costantino, A., Festa, B.M. et al. Oncological outcomes of squamous cell carcinoma of the cervical esophagus treated with definitive (chemo-)radiotherapy: a systematic review and meta-analysis. J Cancer Res Clin Oncol 149, 1029–1041 (2023). https://doi.org/10.1007/s00432-022-03965-8

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  • DOI: https://doi.org/10.1007/s00432-022-03965-8

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