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The effect of surgery plus intensity-modulated radiotherapy on treatment in laryngeal cancer: A clinical retrospective study

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

As a common head and neck tumor, laryngeal cancer has attracted heightened attention for its treatment and prognosis. Surgery and radiotherapy were mainly therapeutic approaches in laryngeal cancer, and intensity-modulated radiotherapy (IMRT) was a precision treatment way in radiotherapy. However, the therapeutic effect of surgery plus IMRT in laryngeal cancer was rarely reported. This study aims to determine the effect of IMRT on the treatment of patients with laryngeal cancer.

Methods

A total of 125 patients with laryngeal cancer were collected and retrospectively analyzed based on their clinical data and follow-up results. These patients had a clear treatment plan for surgery and intensity-modulated radiotherapy.

Results

Smoking, lymph node metastasis, TNM staging and therapeutic approaches could affect the survival of patients with laryngeal cancer. It was shown that the laryngeal function retention rate in the simple IMRT group was significantly higher than the simple surgery group and surgery plus IMRT group. The 5-year survival rate of surgery plus IMRT, simple surgery and simple IMRT were 82.86%, 53.85% and 43.33%, respectively. The locoregional recurrences rate of surgery plus IMRT, simple surgery and simple IMRT were 14.29%, 34.62% and 43.33%.

Conclusion

Surgery plus IMRT was a feasible and efficacious treatment technique for patients with laryngeal cancer, which effectively prolong the survival time of patients.

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Availability of data and materials

The data used to support the findings of this study are available from the corresponding author upon request.

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Funding

This work is supported by the Key Research Program from the Science and Technology Department of Ningxia Hui Autonomous Region, China (2019BFH02012) and the Key Research Program of Hunan Health Committee (20201909), the Program of Hengyang science and Technology Bureau (2017-1, 2020-67), and the Program of Shaoyang science and Technology Bureau (2018FJ19).

Author information

Author notes

  1. Kun Deng, Jingwei Yao, Shuqing Zeng and Meiling Wen contributed equally to this work.

Authors and Affiliations

  1. The Laboratory of Translational Medicine, Hengyang Medical School, University of South China, 28 Changsheng Road, Hengyang, 421001, Hunan, People’s Republic of China

    Kun Deng, Jialu Huang & Jianhong Zuo

  2. Nanhua Hospital of University of South China, Hengyang, 421002, Hunan, People’s Republic of China

    Jingwei Yao, Shanyan Liu & Jianhong Zuo

  3. The First Affiliated Hospital of University of South China, Hengyang, 421000, Hunan, People’s Republic of China

    Shuqing Zeng, Meiling Wen, Tao Zhu & Jianhong Zuo

  4. Clinical Laboratory, The Third Affiliated Hospital of University of South China, Hengyang, 421900, Hunan, People’s Republic of China

    Jianhong Zuo

Authors
  1. Kun Deng
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  2. Jingwei Yao
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  3. Shuqing Zeng
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  4. Meiling Wen
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  5. Jialu Huang
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  6. Tao Zhu
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  7. Shanyan Liu
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  8. Jianhong Zuo
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by JY, SZ, MW, JH and TZ. The first draft of the manuscript was written by KD and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Jianhong Zuo.

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Conflict of interest

The authors declare that they have no competing interests.

Ethics approval

This study was approved by the Ethics Committee of the First Affiliated Hospital of University of South China. Informed consent from patients was obtained prior to enrollment.

Informed consent

As stated in the ethical approval section, each patient provided written informed consent.

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Deng, K., Yao, J., Zeng, S. et al. The effect of surgery plus intensity-modulated radiotherapy on treatment in laryngeal cancer: A clinical retrospective study. J Cancer Res Clin Oncol 148, 517–525 (2022). https://doi.org/10.1007/s00432-021-03637-z

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  • DOI: https://doi.org/10.1007/s00432-021-03637-z

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