Abstract
There is evidence from numerous studies that dysbiosis of the microbiome provokes various immune-mediated diseases, obesity, diabetes, and cancers by regulating metabolites, host genetics, environmental elements, and stress. Such reports are yet to define an accurate regulatory network for host-gut microbiome communication. miRNAs have recently emerged as crucial mediators of this communication, as portrayed by their interaction with the host microbiome. This mini-review summarizes the bi-direction effects between miRNA and microbiome and elucidates their role in carcinogenesis. An in-depth understanding of the association of miRNA with host-microbiome could be valuable to improve cancer remission, diagnosis, and treatment, and may help to potential tumor markers.
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Acknowledgements
We thank all our family for allowing us to conduct this research at the National Natural Science Foundation of China, The Project of Invigorating Health Care through Science, Technology and Education, Jiangsu Provincial Medical Innovation Team, The Project of Invigorating Health Care through Science, Technology and Education, Jiangsu Provincial Medical Outstanding Talent, Young Talents Program of Jiangsu Cancer Hospital.
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This work was supported by the grants from the National Natural Science Foundation of China (Grant No. 82073211, 82002434, 82003106); The Project of Invigorating Health Care through Science, Technology and Education, Jiangsu Provincial Medical Innovation Team (CXTDA2017002); The Project of Invigorating Health Care through Science, Technology and Education, Jiangsu Provincial Medical Outstanding Talent (JCRCA2016001); Young Talents Program of Jiangsu Cancer Hospital (23).
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Wang, Q., Ding, H., Dong, G. et al. Bi-direction effects between microbiome and MiRNAs in carcinogenesis. J Cancer Res Clin Oncol 147, 1299–1305 (2021). https://doi.org/10.1007/s00432-021-03567-w
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DOI: https://doi.org/10.1007/s00432-021-03567-w