Abstract
Purpose
The risk factors and clinical characteristics of ICI-induced immune-mediated hepatotoxicity (IMH) are not fully understood. Thus, the present study sought to clarify the clinical features of IMH.
Methods
All patients treated with ICIs between September 2014 and April 2019 at our institution were included. Clinical data were retrospectively collected from medical records. The frequency of grade ≥ 2 liver damage, clinical characteristics, and risk factors for developing IMH were examined.
Results
Overall, 250 patients (median age 71 years; range 30–87 years; 202 males and 48 females) were included in the analyses. Forty-five patients had elevated transaminase levels (> threefold the upper limit of normal). Of these, 21 were considered to have IMH. The remaining 24 patients had other causes of elevated transaminase levels. Steroids were administered to 13/21 patients with IMH. Although all patients exhibited improvement, IMH was not associated with the anticancer efficacy of the ICIs or OS. A multivariable analysis revealed that IMH was significantly associated with malignant melanoma (odds ratio [OR] 11.6; 95% confidence interval [CI] 3.5–38.0; P = 0.0002) and ipilimumab–nivolumab combination therapy (OR 61.2; 95% CI 7.9–1275.3; P < 0.0001).
Conclusion
Immune-mediated hepatotoxicity occurred in 9.5% of patients treated with ICIs. Appropriate therapeutic interventions are important to avoid affecting the patient’s prognosis, and accurate diagnosis of IMH is essential for this purpose. The frequency of IMH varied according to the type of cancer and the drug used, and was significantly higher in patients with malignant melanoma and in patients given ipilimumab–nivolumab combination therapy.
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Availability of data and materials
All data generated or analyzed during this study are included in this published article.
Abbreviations
- ALT:
-
Alanine aminotransferase
- ANA:
-
Antinuclear antibody
- AST:
-
Aspartate aminotransferase
- CI:
-
Confidence interval
- CTCAE:
-
Common terminology criteria for adverse events
- CTLA-4:
-
Cytotoxic T lymphocyte-associated molecule-4
- DCR:
-
Disease control rate
- ECOG PS:
-
Eastern Cooperative Oncology Group performance status
- Hb:
-
Hemoglobin
- ICI:
-
Immune checkpoint inhibitor
- IMH:
-
Immune-mediated hepatotoxicity
- INR:
-
International normalized ratio
- irAE:
-
Immune-related adverse reaction
- MM:
-
Malignant melanoma
- MMF:
-
Mycophenolate mofetil
- NSCLC:
-
Non-small cell lung cancer
- OR:
-
Odds ratio
- OS:
-
Overall survival
- PD-1:
-
Programmed cell death receptor-1
- PD-L1:
-
Programmed cell death ligand-1
- RECIST:
-
Response evaluation criteria in solid tumors
- RCC:
-
Renal cell carcinoma
- RR:
-
Response rate
- UDCA:
-
Ursodeoxycholic acid
- ULN:
-
Upper limit of the institutional normal
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We thank Stallard Scientific Editing (https://www.stallardediting.com) for editing a draft of this manuscript.
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Study conception and design were performed AY, YY and YU. Material preparation and data collection were performed by AY, EY, YH, HH, RY and NA. Analysis was performed by AY. The first draft of the manuscript was written by AY and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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The study was carried out in accordance with the Declaration of Helsinki and was approved by the institutional review board of the Kobe University Graduate School of Medicine and by the institutional review boards of the participating hospitals (no. B200118). The need to collect informed consent from the patients was waived because this was a retrospective study. Information about this study was published in our institute, and patients could ask for their data to be withdrawn from the analysis.
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Yamamoto, A., Yano, Y., Ueda, Y. et al. Clinical features of immune-mediated hepatotoxicity induced by immune checkpoint inhibitors in patients with cancers. J Cancer Res Clin Oncol 147, 1747–1756 (2021). https://doi.org/10.1007/s00432-020-03448-8
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DOI: https://doi.org/10.1007/s00432-020-03448-8