The P2X7 purinergic receptor: a potential therapeutic target for lung cancer

Li, Qianqian; Zhu, Xiaodi; Song, Wei; Peng, Xiaoxiang; Zhao, Ronglan

doi:10.1007/s00432-020-03379-4

Review – Cancer Research
Published: 05 September 2020

The P2X7 purinergic receptor: a potential therapeutic target for lung cancer

Journal of Cancer Research and Clinical Oncology volume 146, pages 2731–2741 (2020)Cite this article

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Abstract

Purpose

Purinergic P2X7 receptor (P2X7R) is a gated ion channel for which adenosine triphosphate (ATP) is a ligand. Activated P2X7R is widely expressed in a variety of immune cells and tissues and is involved in a variety of physiological and pathological processes. Studies have confirmed that P2X7R is involved in the regulation of tumor cell growth, stimulating cell proliferation or inducing apoptosis. Recent studies have found that P2X7R is abnormally expressed in lung cancer and is closely related to the carcinogenesis and development of lung cancer. In this paper, we comprehensively describe the structure, function, and genetic polymorphisms of P2X7R. In particular, the role and therapeutic potential of P2X7R in lung cancer are discussed to provide new targets and new strategies for the treatment and prognosis of clinical lung cancer.

Methods

The relevant literature on P2X7R and lung cancer from PubMed databases is reviewed in this article.

Results

P2X7R regulates the function of lung cancer cells by activating multiple intracellular signaling pathways (such as the JNK, Rho, HMGB1 and EMT pathways), thereby affecting cell survival, growth, invasion, and metastasis and patient prognosis. Targeting P2X7R with inhibitors effectively suppresses the growth and metastasis of lung cancer cells.

Conclusion

In summary, P2X7R is expected to become a potential target for the treatment of lung cancer, and more clinical research is needed in the future to explore the effectiveness of P2X7R antagonists as treatments.

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This work was supported by the National Natural Science Foundation of China (no. 81770915 and 81301737) and the Major Program of Shandong Province Natural Science Foundation (no. ZR2018ZC1054).

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School of Laboratory Medicine, Weifang Medical University, Weifang, Shandong, China
Qianqian Li, Xiaodi Zhu, Wei Song, Xiaoxiang Peng & Ronglan Zhao

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Qianqian Li
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Xiaodi Zhu
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Wei Song
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Xiaoxiang Peng
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Ronglan Zhao
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Li, Q., Zhu, X., Song, W. et al. The P2X7 purinergic receptor: a potential therapeutic target for lung cancer. J Cancer Res Clin Oncol 146, 2731–2741 (2020). https://doi.org/10.1007/s00432-020-03379-4

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Received: 17 May 2020
Accepted: 01 September 2020
Published: 05 September 2020
Issue Date: November 2020
DOI: https://doi.org/10.1007/s00432-020-03379-4

Keywords

P2X7 receptor
Lung cancer
Adenosine triphosphate
P2X7 receptor antagonist
Purinergic receptor